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Clinical trialNCT00748657CompletedPhase 2Interventional

Bevacizumab in Treating Patients With Recurrent Sex Cord-Stromal Tumors of the Ovary

SponsorNational Cancer Institute (NCI)Enrollment36Malignant Ovarian Epithelial TumorOvarian Granulosa Cell TumorOvarian GynandroblastomaOvarian Sertoli-Leydig Cell TumorOvarian Sex Cord Tumor With Annular TubulesOvarian Sex Cord-Stromal Tumor+2 more conditions
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II trial studies how well bevacizumab works in treating patients with sex cord-stromal tumors of the ovary that have come back. Monoclonal antibodies, such as bevacizumab, may block tumor growth in different ways by targeting certain cells. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

36 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Los Angeles County-Usc Medical Center

    Los Angeles, California, United States

  • Usc / Norris Comprehensive Cancer Center

    Los Angeles, California, United States

  • University of Colorado Hospital

    Aurora, Colorado, United States

  • Hartford Hospital

    Hartford, Connecticut, United States

  • the Hospital of Central Connecticut

    New Britain, Connecticut, United States

  • Northeast Georgia Medical Center-Gainesville

    Gainesville, Georgia, United States

  • Northwestern University

    Chicago, Illinois, United States

  • University of Chicago Comprehensive Cancer Center

    Chicago, Illinois, United States

  • Hinsdale Hematology Oncology Associates Incorporated

    Hinsdale, Illinois, United States

  • Sudarshan K Sharma Md Limted-Gynecologic Oncology

    Hinsdale, Illinois, United States

  • University of Iowa/holden Comprehensive Cancer Center

    Iowa City, Iowa, United States

  • Massachusetts General Hospital Cancer Center

    Boston, Massachusetts, United States

  • University of Massachusetts Medical School

    Worcester, Massachusetts, United States

  • University of Massachusetts Memorial Health Care

    Worcester, Massachusetts, United States

  • University of Minnesota/masonic Cancer Center

    Minneapolis, Minnesota, United States

  • University of Mississippi Medical Center

    Jackson, Mississippi, United States

  • Nebraska Methodist Hospital

    Omaha, Nebraska, United States

  • Memorial Sloan-Kettering Cancer Center

    New York, New York, United States

  • Carolinas Medical Center/levine Cancer Institute

    Charlotte, North Carolina, United States

  • Duke University Medical Center

    Durham, North Carolina, United States

  • Case Western Reserve University

    Cleveland, Ohio, United States

  • Cleveland Clinic Cancer Center/fairview Hospital

    Cleveland, Ohio, United States

  • Cleveland Clinic Foundation

    Cleveland, Ohio, United States

  • Metrohealth Medical Center

    Cleveland, Ohio, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, United States

  • Riverside Methodist Hospital

    Columbus, Ohio, United States

  • Miami Valley Hospital

    Dayton, Ohio, United States

  • Hillcrest Hospital Cancer Center

    Mayfield Heights, Ohio, United States

  • Lake University Ireland Cancer Center

    Mentor, Ohio, United States

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, United States

  • Oklahoma Cancer Specialists and Research Institute-Tulsa

    Tulsa, Oklahoma, United States

  • Abington Memorial Hospital

    Abington, Pennsylvania, United States

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania, United States

  • Parkland Memorial Hospital

    Dallas, Texas, United States

  • Ut Southwestern/simmons Cancer Center-Dallas

    Dallas, Texas, United States

  • M D Anderson Cancer Center

    Houston, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
22 Sept 2008
Primary completion
31 Jan 2013
Completion
31 Jan 2013
Last update posted
23 Jul 2019
Registered enrollment
36
Registry id
NCT00748657

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.