Clinical trialNCT00781742CompletedPhase 2Interventional

AZD6765 Severe Major Depressive Disorder (MDD) IV

SponsorAstraZenecaEnrollment152Major Depressive Disorder

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this research study is to determine whether AZD6765 has an effect on the patient's depression when taken together with current depression medication. In addition, information will be gathered on how well AZD6765 is tolerated, investigate the levels of AZD6765 and the levels of the current depression medication in the blood. In addition, the research staff will determine if AZD6765 has any mood or calming effects (how you feel).

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Gerard Sanacora
Yale University
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗
Michael Castiglione
AstraZeneca
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

27 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Research Site
Little Rock, Arkansas, United States
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Los Angeles, California, United States
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Orange, California, United States
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San Diego, California, United States
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Santa Ana, California, United States
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Hartford, Connecticut, United States
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New Haven, Connecticut, United States
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Boca Raton, Florida, United States
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Gainsville, Florida, United States
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Hollywood, Florida, United States
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Jacksonville, Florida, United States
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Atlanta, Georgia, United States
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Roswell, Georgia, United States
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Hoffman Estates, Illinois, United States
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Joliet, Illinois, United States
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Overland Park, Kansas, United States
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Lake Charles, Louisiana, United States
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Shreveport, Louisiana, United States
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Haverhill, Massachusetts, United States
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St Louis, Missouri, United States
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Willingboro, New Jersey, United States
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Albuquerque, New Mexico, United States
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Rochester, New York, United States
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East Stroudsburg, Pennsylvania, United States
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Philadelphia, Pennsylvania, United States
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Austin, Texas, United States
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Dallas, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

AZD6765Placebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Oct 2008
Primary completion: 31 Mar 2010
Completion: 31 Mar 2010
Last update posted: 25 Jul 2012
Registered enrollment: 152
Registry id: NCT00781742

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.