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Clinical trialNCT00782340CompletedPhase 3Interventional

A Clinical Study for Patients With Neurogenic Orthostatic Hypotension (NOH) Using Droxidopa

SponsorChelsea TherapeuticsEnrollment263Dopamine Beta Hydroxylase DeficiencyNon-diabetic NeuropathyPrimary Autonomic FailureSymptomatic Neurogenic Orthostatic Hypotension (NOH)
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to see whether droxidopa is effective in treating symptoms of neurogenic orthostatic hypotension in patients with Primary Autonomic Failure (Pure Autonomic Failure, Multiple System Atrophy, Parkinson's Disease), Non-diabetic neuropathy, or Beta Hydroxylase deficiency.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

21 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada
  • University of Calgary

    Calgary, Alberta, Canada

  • University of Alberta

    Edmonton, Alberta, Canada

  • Movment Disorder Clinic Deer Lodge Centre

    Winnipeg, Manitoba, Canada

  • David B. King, - Private Clinic

    Halifax, Nova Scotia, Canada

  • London Health Sciences Centre, Uh

    London, Ontario, Canada

  • Uhnresearch

    Toronto, Ontario, Canada

  • Ircm

    Montreal, Quebec, Canada

United States
  • North Alabama Neuroscience

    Huntsville, Alabama, United States

  • Mayo Clinic-Arizona

    Scottsdale, Arizona, United States

  • Arkansas Cardiology

    Little Rock, Arkansas, United States

  • University of California, Irvine

    Irvine, California, United States

  • Bradenton Neurology, Inc

    Bradenton, Florida, United States

  • Suncoast Neuroscience Associates, Inc

    St. Petersburg, Florida, United States

  • University of Kansas Medical Center

    Kansas City, Kansas, United States

  • Cncs, Ninds,nih

    Bethesda, Maryland, United States

  • Nerological Reserch Center at Hattiesburg

    Hattiesburg, Mississippi, United States

  • North Shore Hospital

    Manshasette, New York, United States

  • Pennsylvania Hospital of the University of Pa Health System- Department of Neurology

    Philadelphia, Pennsylvania, United States

  • Han Neurological Associates

    Upland, Pennsylvania, United States

  • Baylor College of Medicine

    Houston, Texas, United States

  • Evergreen Hospital Medical Center; Booth Gardner Parkinson'S Care Center

    Kirkland, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Droxidopa →Placebo
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
30 Sept 2008
Primary completion
30 Sept 2010
Completion
30 Sept 2010
Last update posted
16 May 2014
Registered enrollment
263
Registry id
NCT00782340
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.