Clinical trialNCT00787969CompletedPhase 1Interventional

Rituximab, Cladribine, and Temsirolimus in Treating Patients With Newly Diagnosed Mantle Cell Lymphoma

SponsorAlliance for Clinical Trials in OncologyEnrollment74Lymphoma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase I/II trial studies the side effects and best dose of temsirolimus when given together with cladribine and rituximab and to see how well it works in treating patients with newly diagnosed mantle cell lymphoma. Monoclonal antibodies, such as rituximab, may interfere with the ability of cancer cells to grow and spread. Drugs used in chemotherapy, such as cladribine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Temsirolimus may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving temsirolimus together with cladribine and rituximab may kill more cancer cells.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

David J. Inwards, MD
Mayo Clinic
Study Chair
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

144 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Mayo Clinic Scottsdale
Scottsdale, Arizona, United States
Illinois Cancercare - Bloomington
Bloomington, Illinois, United States
St. Joseph Medical Center
Bloomington, Illinois, United States
Graham Hospital
Canton, Illinois, United States
Illinois Cancercare - Canton
Canton, Illinois, United States
Illinois Cancercare - Carthage
Carthage, Illinois, United States
Memorial Hospital
Carthage, Illinois, United States
Eureka Community Hospital
Eureka, Illinois, United States
Illinois Cancercare - Eureka
Eureka, Illinois, United States
Galesburg Clinic, Pc
Galesburg, Illinois, United States
Illinois Cancercare - Galesburg
Galesburg, Illinois, United States
Illinois Cancercare - Havana
Havana, Illinois, United States
Mason District Hospital
Havana, Illinois, United States
Illinois Cancercare - Kewanee Clinic
Kewanee, Illinois, United States
Illinois Cancercare - Macomb
Macomb, Illinois, United States
Mcdonough District Hospital
Macomb, Illinois, United States
Illinois Cancercare - Monmouth
Monmouth, Illinois, United States
Osf Holy Family Medical Center
Monmouth, Illinois, United States
Bromenn Regional Medical Center
Normal, Illinois, United States
Community Cancer Center
Normal, Illinois, United States
Illinois Cancercare - Community Cancer Center
Normal, Illinois, United States
Community Hospital of Ottawa
Ottawa, Illinois, United States
Oncology Hematology Associates of Central Illinois, Pc - Ottawa
Ottawa, Illinois, United States
Cancer Treatment Center at Pekin Hospital
Pekin, Illinois, United States
Illinois Cancercare - Pekin
Pekin, Illinois, United States
Ccop - Illinois Oncology Research Association
Peoria, Illinois, United States
Methodist Medical Center of Illinois
Peoria, Illinois, United States
Osf St. Francis Medical Center
Peoria, Illinois, United States
Oncology Hematology Associates of Central Illinois, Pc - Peoria
Peoria, Illinois, United States
Proctor Hospital
Peoria, Illinois, United States
Illinois Cancercare - Peru
Peru, Illinois, United States
Illinois Valley Community Hospital
Peru, Illinois, United States
Illinois Cancercare - Princeton
Princeton, Illinois, United States
Perry Memorial Hospital
Princeton, Illinois, United States
Illinois Cancercare - Spring Valley
Spring Valley, Illinois, United States
Elkhart Clinic, Llc
Elkhart, Indiana, United States
Elkhart General Hospital
Elkhart, Indiana, United States
Michiana Hematology-Oncology, Pc - Elkhart
Elkhart, Indiana, United States
Howard Community Hospital
Kokomo, Indiana, United States
Center for Cancer Therapy at Laporte Hospital and Health Services
La Porte, Indiana, United States

104 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Filgrastim →Pegfilgrastim →Cladribine →Rituximab →Temsirolimus →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Apr 2009
Primary completion: 30 Apr 2012
Completion: 15 Jun 2017
Last update posted: 9 Jan 2018
Registered enrollment: 74
Registry id: NCT00787969

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.