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Clinical trialNCT00799773TerminatedPhase 3Interventional

Evaluating the Effectiveness of Adding Rituximab to Standard Treatment for Thrombotic Thrombocytopenic Purpura (TTP)

SponsorCarelon ResearchEnrollment3Thrombotic Thrombocytopenic Purpura
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Thrombotic thrombocytopenic purpura (TTP) is a rare disorder that causes blood clots to form in blood vessels. The main treatment for TTP is plasma exchange, in which affected patients receive transfusions of plasma, the liquid part of blood, from healthy donors. This study will examine the effectiveness of an antibody, rituximab, in combination with plasma exchange, at improving the immune response in people with TTP and decreasing the recurrence of TTP.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

23 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • University of Alabama, Birmingham

    Birmingham, Alabama, United States

  • Emory University

    Atlanta, Georgia, United States

  • University of Iowa

    Iowa City, Iowa, United States

  • Tulane University Health Sciences Center

    New Orleans, Louisiana, United States

  • Johns Hopkins Hospital

    Baltimore, Maryland, United States

  • University of Maryland Medical Center

    Baltimore, Maryland, United States

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, United States

  • Brigham and Women'S Hospital

    Boston, Massachusetts, United States

  • Children'S Hospital Boston

    Boston, Massachusetts, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, United States

  • New York-Presbyterian Hospital/weill Cornell Medical Center

    New York, New York, United States

  • University of North Carolina Hospitals

    Chapel Hill, North Carolina, United States

  • Duke University Medical Center

    Durham, North Carolina, United States

  • University Hospital Cleveland

    Cleveland, Ohio, United States

  • Integris Baptist Medical Center

    Oklahoma City, Oklahoma, United States

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, United States

  • Children'S Hospital of Pittsburgh

    Pittsburgh, Pennsylvania, United States

  • University of Pittsburgh Presbyterian and Shadyside Hospital

    Pittsburgh, Pennsylvania, United States

  • Puget Sound Blood Center

    Seattle, Washington, United States

  • Gunderson Clinic, Ltd

    La Crosse, Wisconsin, United States

  • University of Wisconsin at Madison

    Madison, Wisconsin, United States

  • Froedtert Memorial Lutheran Hospital

    Milwaukee, Wisconsin, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

CorticosteroidsRituximab →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
30 Apr 2009
Primary completion
28 Feb 2010
Completion
28 Feb 2010
Last update posted
22 Jul 2013
Registered enrollment
3
Registry id
NCT00799773

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.