Clinical trialNCT00803062CompletedPhase 3Interventional

Paclitaxel and Cisplatin or Topotecan With or Without Bevacizumab in Treating Patients With Stage IVB, Recurrent, or Persistent Cervical Cancer

SponsorNational Cancer Institute (NCI)Enrollment452Cervical AdenocarcinomaCervical Adenosquamous CarcinomaCervical Squamous Cell CarcinomaRecurrent Cervical CarcinomaStage IVB Cervical Cancer

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This randomized phase III trial studies the side effects of paclitaxel when given together with cisplatin or topotecan with or without bevacizumab and to compare how well they work in treating patients with stage IVB, cervical cancer that has come back or is persistent. Drugs used in chemotherapy, such as paclitaxel, cisplatin, and topotecan, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as bevacizumab, may interfere with the ability of tumor cells to grow and spread. It is not yet known whether paclitaxel is more effective when given together with cisplatin or topotecan with or without bevacizumab in treating patients with cervical cancer.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Krishnansu Tewari
NRG Oncology
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

549 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Spain

Vall D'Hebron University Hospital
Barcelona, Spain
Hospital Reina Sofia
Córdoba, Spain
Hospital Universitari de Girona Doctor Josep Trueta
Girona, Spain
Hospital Universitario Gregorio Maranon
Madrid, Spain
Hospital Universitario la Paz
Madrid, Spain
M D Anderson International Spain
Madrid, Spain
Hospital Son Llatzer
Palma, Spain
Instituto Valenciano de Oncologia
Valencia, Spain

United States

University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, United States
University of South Alabama Mitchell Cancer Institute
Mobile, Alabama, United States
Saint Joseph'S Hospital and Medical Center
Phoenix, Arizona, United States
Highlands Oncology Group Pa - Fayetteville
Fayetteville, Arkansas, United States
Washington Regional Medical Center - Fayetteville
Fayetteville, Arkansas, United States
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California, United States
Providence Saint Joseph Medical Center/disney Family Cancer Center
Burbank, California, United States
Roy and Patricia Disney Family Cancer Center
Burbank, California, United States
Mills - Peninsula Hospitals
Burlingame, California, United States
John Muir Medical Center-Concord Campus
Concord, California, United States
City of Hope Comprehensive Cancer Center
Duarte, California, United States
California Cancer Center - North Fresno
Fresno, California, United States
Long Beach Memorial Medical Center-Todd Cancer Institute
Long Beach, California, United States
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, United States
Los Angeles County-Usc Medical Center
Los Angeles, California, United States
Ucla / Jonsson Comprehensive Cancer Center
Los Angeles, California, United States
Usc / Norris Comprehensive Cancer Center
Los Angeles, California, United States
Palo Alto Medical Foundation-Gynecologic Oncology
Mountain View, California, United States
Sutter Cancer Research Consortium
Novato, California, United States
Saint Joseph Hospital - Orange
Orange, California, United States
Uc Irvine Health/chao Family Comprehensive Cancer Center
Orange, California, United States
Stanford Cancer Institute
Palo Alto, California, United States
University of California Davis Comprehensive Cancer Center
Sacramento, California, United States
University of California San Diego
San Diego, California, United States
California Pacific Medical Center-Pacific Campus
San Francisco, California, United States
Ucsf Medical Center-Mount Zion
San Francisco, California, United States
Olive View-University of California Los Angeles Medical Center
Sylmar, California, United States
Sutter Solano Medical Center/cancer Center
Vallejo, California, United States
John Muir Medical Center-Walnut Creek
Walnut Creek, California, United States
Colorado Gynecologic Oncology Group
Aurora, Colorado, United States
the Medical Center of Aurora
Aurora, Colorado, United States

509 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Bevacizumab →Cisplatin →Paclitaxel →Topotecan →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Apr 2009
Primary completion: 28 Feb 2013
Completion: 28 Feb 2013
Last update posted: 23 Jul 2019
Registered enrollment: 452
Registry id: NCT00803062

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.