Clinical trialNCT00813813CompletedPhase 1/PHASE2Interventional

Intradiscal rhGDF-5 Phase I/II Clinical Trial

SponsorDePuy SpineEnrollment32Degenerative Disc Disease

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Study to show the effectiveness and safety of a single injection of rhGDF5 into a degenerating single spinal disc in treating lumbar level degenerative disc disease

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

James Rathmell, MD
Massachusetts General Hospital
Principal Investigator
clinicaltrials.gov ↗
Jim Youssef, MD
Durango Orthopedic Associates/Spine Colorado
Principal Investigator
clinicaltrials.gov ↗
Jonathan Borden, MD
Riverhills Healthcare, Inc.
Principal Investigator
clinicaltrials.gov ↗
Marvin Tark, MD
Drug Study America
Principal Investigator
clinicaltrials.gov ↗
Norman Harden, MD
Shirley Ryan AbilityLab
Principal Investigator
clinicaltrials.gov ↗
Richard Guyer, MD
Texas Back Institute
Principal Investigator
clinicaltrials.gov ↗
Yaoming Gu, MD
Virginia Commonwealth University
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

8 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Spine Institute
Santa Monica, California, United States
Durango Orthopedic Associates/spine Colorado
Durango, Colorado, United States
Drug Studies America
Marietta, Georgia, United States
Rehabilitation Institute of Chicago
Chicago, Illinois, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Riverhills Healthcare, Inc.
Cincinnati, Ohio, United States
Tbi Clinical Research, Llc
Plano, Texas, United States
Virginia Commonwealth University Spine Center
Richmond, Virginia, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Intradiscal rhGDF-5

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Jun 2008
Primary completion: 30 Jun 2013
Completion: 30 Jun 2013
Last update posted: 26 Feb 2016
Registered enrollment: 32
Registry id: NCT00813813

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.