Clinical trialNCT00848523TerminatedPhase 2Interventional

Study of LBH589 (Panobinostat) to Treat Malignant Brain Tumors

SponsorNeurological Surgery, P.C.Enrollment6Recurrent Malignant Gliomas

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The drug LBH589 (panobinostat) is an experimental (investigational) drug that is being tested for recurrent (returning) malignant gliomas. An investigational drug is one that has not been approved by the U.S. Food and Drug Administration (FDA). It belongs to a new class of drugs called "histone deacetylase inhibitors." Histones are proteins located in the nucleus of cells that bind to DNA, the chemical that makes up genes. These proteins help control which genes are turned "on" and "off." Studies have shown that drugs like panobinostat (LBH589) may lead to tumor cell death.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

J. Paul Duic, MD
Long Island Brain Tumor Center at Neurological Surgery PC / Long Island Neuro-Oncology Associates
Principal Investigator
clinicaltrials.gov ↗
Jai Grewal, MD
Long Island Brain Tumor Center at Neurological Surgery PC/ Long Island Neuro-oncology Associates
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

2 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Long Island Brain Tumor Center at Neurological Surgery Pc / Long Island Neuro-Oncology Associates
Commack, New York, United States
Long Island Brain Tumor Center at Neurological Surgery Pc / Long Island Neuro-Oncology Associates
Great Neck, New York, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Panobinostat →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Nov 2008
Primary completion: 30 Apr 2009
Completion: 30 Apr 2009
Last update posted: 16 Jul 2010
Registered enrollment: 6
Registry id: NCT00848523

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.