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Clinical trialNCT00853489TerminatedPhase 4Interventional

rhBMP-2 Versus Autograft in Critical Size Tibial Defects

SponsorSt. Louis UniversityEnrollment33Tibial Fractures
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of our study is to evaluate the use of recombinant human bone morphogenetic protein 2 (RhBMP-2) as compared to standard ICBG in the treatment of severe open tibia fractures with a critical size bone defect (at least one centimeter in length compromising at least 50% of the circumference of the bone).
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

13 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Ucsf Medical Center

    San Francisco, California, United States

  • Denver Health and Hospital Authority

    Denver, Colorado, United States

  • Florida Orthopaedic Institute / Tampa General & St. Joseph'S Hospitals

    Tampa, Florida, United States

  • University of Iowa Hospitals

    Iowa City, Iowa, United States

  • Boston Medical Center

    Boston, Massachusetts, United States

  • Hennepin County Medical Center

    Minneapolis, Minnesota, United States

  • St. Louis Medical Center

    St Louis, Missouri, United States

  • Carolinas Medical Center

    Charlotte, North Carolina, United States

  • Metrohealth Medical Center

    Cleveland, Ohio, United States

  • University of Oklahoma / Ou Medical Center

    Oklahoma City, Oklahoma, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, United States

  • Brooke Army Medical Center

    Fort Sam Houston, Texas, United States

  • University of Washington / Harborview Medical Center

    Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Aug 2011
Primary completion
17 Feb 2017
Completion
17 Feb 2017
Last update posted
25 Oct 2018
Registered enrollment
33
Registry id
NCT00853489
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.