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Clinical trialNCT00866307CompletedPhase 1Interventional

Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia (Closed to Accrual 4-22-2011)

SponsorChildren's Oncology GroupEnrollment104Acute Lymphoblastic LeukemiaAdult B Acute Lymphoblastic LeukemiaChildhood B Acute Lymphoblastic Leukemia
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This pilot clinical trial studies the side effects of pegaspargase when given together with combination chemotherapy in treating patients with newly diagnosed high-risk acute lymphoblastic leukemia. Pegaspargase may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) together with pegaspargase may kill more cancer cells.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

28 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia
  • Royal Children'S Hospital

    Parkville, Victoria, Australia

  • Princess Margaret Hospital for Children

    Perth, Western Australia, Australia

Canada
  • Children'S Hospital of Eastern Ontario

    Ottawa, Ontario, Canada

United States
  • Phoenix Childrens Hospital

    Phoenix, Arizona, United States

  • Miller Children'S and Women'S Hospital Long Beach

    Long Beach, California, United States

  • Children'S Hospital Los Angeles

    Los Angeles, California, United States

  • Valley Children'S Hospital

    Madera, California, United States

  • Rady Children'S Hospital - San Diego

    San Diego, California, United States

  • Ucsf Medical Center-Mount Zion

    San Francisco, California, United States

  • Ucsf Medical Center-Parnassus

    San Francisco, California, United States

  • Harbor-University of California at Los Angeles Medical Center

    Torrance, California, United States

  • Nemours Children'S Clinic-Jacksonville

    Jacksonville, Florida, United States

  • Children'S Healthcare of Atlanta - Egleston

    Atlanta, Georgia, United States

  • Advocate Children'S Hospital-Oak Lawn

    Oak Lawn, Illinois, United States

  • Saint Vincent Hospital and Health Care Center

    Indianapolis, Indiana, United States

  • University of Kentucky/markey Cancer Center

    Lexington, Kentucky, United States

  • Norton Children'S Hospital

    Louisville, Kentucky, United States

  • C S Mott Children'S Hospital

    Ann Arbor, Michigan, United States

  • University of Mississippi Medical Center

    Jackson, Mississippi, United States

  • the Steven and Alexandra Cohen Children'S Medical Center of New York

    New Hyde Park, New York, United States

  • Unc Lineberger Comprehensive Cancer Center

    Chapel Hill, North Carolina, United States

  • Nationwide Children'S Hospital

    Columbus, Ohio, United States

  • Dayton Children'S Hospital

    Dayton, Ohio, United States

  • Legacy Emanuel Children'S Hospital

    Portland, Oregon, United States

  • Legacy Emanuel Hospital and Health Center

    Portland, Oregon, United States

  • Children'S Oncology Group

    Philadelphia, Pennsylvania, United States

  • Baylor College of Medicine/dan L Duncan Comprehensive Cancer Center

    Houston, Texas, United States

  • Methodist Children'S Hospital of South Texas

    San Antonio, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
23 Feb 2009
Primary completion
30 Jun 2014
Completion
31 Mar 2021
Last update posted
27 Apr 2021
Registered enrollment
104
Registry id
NCT00866307

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.