Clinical trialNCT00869206CompletedPhase 3Interventional

Zoledronic Acid in Treating Patients With Metastatic Breast Cancer, Metastatic Prostate Cancer, or Multiple Myeloma With Bone Involvement

SponsorAlliance for Clinical Trials in OncologyEnrollment1,822Breast AdenocarcinomaDS Stage I Plasma Cell MyelomaDS Stage II Plasma Cell MyelomaMetastatic Malignant Neoplasm to the BonePainMusculoskeletal Complication+1 more conditions

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This randomized phase III trial studies two different schedules of zoledronic acid to compare how well they work in reducing bone-related complications in patients with breast cancer, prostate cancer, or multiple myeloma that has spread to other places in the body and have bone involvement. Bone-related complications are a major cause of morbidity in patients with metastatic prostate cancer, breast cancer, and multiple myeloma. Zoledronic acid may stop the growth of cancer cells in the bone and may help relieve some of the symptoms caused by bone metastases. It is not yet known whether giving zoledronic acid more or less frequently is more effective in treating patients with metastatic cancer that has spread to the bone.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Andrew L. Himelstein, MD
Helen F. Graham Cancer Center at Christiana Hospital
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

504 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Puerto Rico

San Juan City Hospital
San Juan, Puerto Rico

United States

Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital
Fairbanks, Alaska, United States
Mayo Clinic Scottsdale
Scottsdale, Arizona, United States
East Bay Radiation Oncology Center
Castro Valley, California, United States
Valley Medical Oncology Consultants - Castro Valley
Castro Valley, California, United States
North Bay Cancer Center
Fairfield, California, United States
Valley Medical Oncology
Fremont, California, United States
Rebecca and John Moores Ucsd Cancer Center
La Jolla, California, United States
Contra Costa Regional Medical Center
Martinez, California, United States
Memorial Medical Center
Modesto, California, United States
Camino Medical Group - Treatment Center
Mountain View, California, United States
El Camino Hospital Cancer Center
Mountain View, California, United States
Leavey Cancer Center at Northridge Hospital Medical Center
Northridge, California, United States
Alta Bates Summit Medical Center - Summit Campus
Oakland, California, United States
Bay Area Breast Surgeons, Incorporated
Oakland, California, United States
Ccop - Bay Area Tumor Institute
Oakland, California, United States
Highland General Hospital
Oakland, California, United States
Larry G Strieff Md Medical Corporation
Oakland, California, United States
Tom K Lee, Incorporated
Oakland, California, United States
Palo Alto Medical Foundation
Palo Alto, California, United States
Feather River Hospital Cancer Center
Paradise, California, United States
Facility name not stated
Pismo Beach, California, United States
Naval Medical Center - San Diego
San Diego, California, United States
Veterans Affairs Medical Center - San Diego
San Diego, California, United States
Doctors Medical Center - San Pablo Campus
San Pablo, California, United States
Aurora Presbyterian Hospital
Aurora, Colorado, United States
Boulder Community Hospital
Boulder, Colorado, United States
Memorial Hospital Cancer Center - Colorado Springs
Colorado Springs, Colorado, United States
Penrose Cancer Center at Penrose Hospital
Colorado Springs, Colorado, United States
Ccop - Colorado Cancer Research Program
Denver, Colorado, United States
Porter Adventist Hospital
Denver, Colorado, United States
Presbyterian - St. Luke'S Medical Center
Denver, Colorado, United States
Rose Medical Center
Denver, Colorado, United States
St. Anthony Central Hospital
Denver, Colorado, United States
St. Joseph Hospital
Denver, Colorado, United States
Swedish Medical Center
Englewood, Colorado, United States
Front Range Cancer Specialists
Fort Collins, Colorado, United States
Poudre Valley Hospital
Fort Collins, Colorado, United States
St. Mary'S Regional Cancer Center at St. Mary'S Hospital and Medical Center
Grand Junction, Colorado, United States
North Colorado Medical Center
Greeley, Colorado, United States

464 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Zoledronic acid →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Mar 2009
Primary completion: 30 Jun 2014
Completion: 31 Jan 2017
Last update posted: 7 Nov 2018
Registered enrollment: 1,822
Registry id: NCT00869206

Cross-registrations

Other registry (NCI Physician Data QueryCDR0000637947Other registry (NCI Clinical Trial Reporting ProgramNCI-2009-01102

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.