Clinical trialNCT00878644CompletedPhase 3Interventional

Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-OH [Out of Hospital] Trial

SponsorUniversity of MichiganEnrollment295Cardiac Arrest

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Cardiac arrest is a sudden, unexpected loss of heart function. Therapeutic hypothermia, in which the body's temperature is lowered and maintained several degrees below normal for a period of time, has been used to successfully treat adults who have experienced cardiac arrest. This study will evaluate the efficacy of therapeutic hypothermia at increasing survival rates and reducing the risk of brain injury in infants and children who experience a cardiac arrest while out of the hospital.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Frank W Moler, MD, MS
University of Michigan
Principal Investigator
clinicaltrials.gov ↗
Michael Dean, MD, MBA
University of Utah
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

34 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

the Hospital for Sick Children
Toronto, Ontario, Canada

United States

the Children'S Hospital of Alabama
Birmingham, Alabama, United States
Phoenix Children'S Hospital
Phoenix, Arizona, United States
University of Arizona at Tucson
Tucson, Arizona, United States
Loma Linda University Children'S Hospital
Loma Linda, California, United States
Children'S Hospital of Los Angeles
Los Angeles, California, United States
University of California Los Angeles
Los Angeles, California, United States
Children'S Hospital of Orange County
Orange, California, United States
University of California San Francisco
San Francisco, California, United States
Children'S Hospital of Denver/university of Colorado
Denver, Colorado, United States
Children'S National Medical Center
Washington D.C., District of Columbia, United States
Children'S Hospital of Atlanta/emory University
Atlanta, Georgia, United States
Children'S Memorial Hospital
Chicago, Illinois, United States
Kosair Children'S Hospital
Louisville, Kentucky, United States
Johns Hopkins Children'S Center
Baltimore, Maryland, United States
University of Michigan, Mott Children'S Hospital
Ann Arbor, Michigan, United States
Children'S Hospital of Michigan
Detroit, Michigan, United States
Children'S Hospital and Clinics of Minnesota
Minneapolis, Minnesota, United States
Washington University in St. Louis
St Louis, Missouri, United States
Children'S Hospital of New York - Columbia University Medical Center
New York, New York, United States
University of Rochester Medical Center
Rochester, New York, United States
Duke Children'S Hospital
Durham, North Carolina, United States
Cincinnati Children'S Hospital
Cincinnati, Ohio, United States
Rainbow Babies and Children
Cleveland, Ohio, United States
Nationwide Children'S Hospital in Columbus
Columbus, Ohio, United States
Penn State Children'S Hospital
Hershey, Pennsylvania, United States
Children'S Hospital of Philidelphia
Philadelphia, Pennsylvania, United States
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States
Lebonheur Children'S Hospital - University of Tennessee at Memphis
Memphis, Tennessee, United States
Children'S Medical Center Dallas
Dallas, Texas, United States
University of Texas Health Sciences Center of San Antonio
San Antonio, Texas, United States
Primary Children'S Medical Center
Salt Lake City, Utah, United States
Seatlle Children'S Hospital
Seattle, Washington, United States
Medical College of Wisconsin/children'S Hospital of Wisconsin
Milwaukee, Wisconsin, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Sept 2009
Primary completion: 30 Jun 2014
Completion: 30 Jun 2014
Last update posted: 29 Sept 2017
Registered enrollment: 295
Registry id: NCT00878644

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.