Clinical trialNCT00879437CompletedPhase 2Interventional

Valproic Acid, Radiation, and Bevacizumab in Children With High Grade Gliomas or Diffuse Intrinsic Pontine Glioma

SponsorBaylor College of MedicineEnrollment38Anaplastic AstrocytomaBrainstem GliomaDiffuse Intrinsic Pontine GliomaGlial Cell TumorsGlioblastoma MultiformeGliomatosis Cerebri+2 more conditions

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Currently, there are few effective treatments for the following aggressive brain tumors: glioblastoma multiforme, anaplastic astrocytoma, gliomatosis cerebri, gliosarcoma, or brainstem glioma. Surgery and radiation can generally slow down these aggressive brain tumors, but in the majority of patients, these tumors will start growing again in 6-12 months. Adding chemotherapy drugs to surgery and radiation does not clearly improve the cure rate of children with malignant gliomas. The investigators are conducting this study to see if the combination of valproic acid and bevacizumab (also known as AvastinTM) with surgery and radiation will shrink these brain tumors more effectively and improve the chance of cure.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Jack Su, MD
Baylor College of Medicine
Study Chair
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

6 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States
Children'S Medical Center Dallas, Center for Cancer and Blood Disorders
Dallas, Texas, United States
Cook Children'S Medical Center
Fort Worth, Texas, United States
Md Anderson Cancer Center
Houston, Texas, United States
Texas Children'S Hospital
Houston, Texas, United States
University of Texas Health Science Center
San Antonio, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Bevacizumab →Valproate →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 1 Sept 2009
Primary completion: 30 Aug 2015
Completion: 2 Oct 2017
Last update posted: 21 Jul 2021
Registered enrollment: 38
Registry id: NCT00879437

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.