Clinical trialNCT00887146Active, not recruitingPhase 3Interventional

Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma

SponsorAlliance for Clinical Trials in OncologyEnrollment305Brain and Central Nervous System Tumors

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether giving radiation with concomitant and adjuvant temozolomide versus radiation with adjuvant PCV is more effective in treating anaplastic glioma or low grade glioma.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Kurt Jaeckle, MD
Mayo Clinic
Study Chair
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

291 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Austria

Medical University Vienna
Vienna, Austria

Belgium

Alegemeen Ziekenhuis Middelheim
Antwerp, Belgium

Canada

Tom Baker Cancer Centre
Calgary, Alberta, Canada
Cross Cancer Institute
Edmonton, Alberta, Canada
Bcca-Vancouver Cancer Centre
Vancouver, British Columbia, Canada
Cancercare Manitoba
Winnipeg, Manitoba, Canada
London Regional Cancer Program
London, Ontario, Canada
Ottawa Hospital and Cancer Center-General Campus
Ottawa, Ontario, Canada
Odette Cancer Centre- Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada
University Health Network-Princess Margaret Hospital
Toronto, Ontario, Canada
Chum - Centre Hospitalier de L'Universite de Montreal
Montreal, Quebec, Canada
Chum - Hopital Notre-Dame
Montreal, Quebec, Canada
Allan Blair Cancer Centre
Regina, Saskatchewan, Canada

France

Centre Leon Berard
Lyon, France
Centre Antoine Lacassagne
Nice, France
Gustave Roussy
Villejuif, France

Netherlands

Academ Zienkenhuis Bij de University
Amsterdam, Netherlands
University Medical Center Groningen
Groningen, Netherlands
Maastro Clinic-Maastricht Radiation Oncology
Maastricht, Netherlands
Erasmus University Medical Center
Rotterdam, Netherlands

United States

University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, United States
Providence Hospital
Mobile, Alabama, United States
Alaska Oncology and Hematology Llc
Anchorage, Alaska, United States
Alaska Women'S Cancer Care
Anchorage, Alaska, United States
Anchorage Associates in Radiation Medicine
Anchorage, Alaska, United States
Anchorage Oncology Centre
Anchorage, Alaska, United States
Katmai Oncology Group
Anchorage, Alaska, United States
Providence Alaska Medical Center
Anchorage, Alaska, United States
Arizona Oncology-Deer Valley Center
Phoenix, Arizona, United States
Saint Joseph'S Hospital and Medical Center
Phoenix, Arizona, United States
Arizona Oncology Services Foundation
Scottsdale, Arizona, United States
Kaiser Permanente-Anaheim
Anaheim, California, United States
Sutter Cancer Centers Radiation Oncology Services-Auburn
Auburn, California, United States
Mills-Peninsula Medical Center
Burlingame, California, United States
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Cameron Park, California, United States
Community Cancer Institute
Clovis, California, United States
University Oncology Associates
Clovis, California, United States
Uc San Diego Moores Cancer Center
La Jolla, California, United States
Cedars Sinai Medical Center
Los Angeles, California, United States
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, United States

251 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

CCNUAdjuvant temozolomideConcomitant temozolomideProcarbazine →Vincristine →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Sept 2009
Primary completion: 31 Oct 2029
Completion: 31 Oct 2029
Last update posted: 22 Jan 2026
Registered enrollment: 305
Registry id: NCT00887146

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.