Clinical trialNCT00897702CompletedObservational

Molecular Mechanisms of Clinical Resistance to Targeted Therapy Among Patients With Breast Cancer

SponsorMemorial Sloan Kettering Cancer CenterEnrollment269Breast Cancer

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to learn why certain drugs stop working in patients.In lab studies, tumors become resistant in several ways. Specific molecules seem to change and this may be why therapy stops working. However, we do not know if the same molecules change in patients. This study is being done to see if they do change. If we learn more about how patients become resistant, we may be able to offer better treatment in the future.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Sarat Chandarlapaty, MD, PhD
Memorial Sloan Kettering Cancer Center
Study ChairKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

7 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Memorial Sloan Kettering Basking Ridge (consent Only)
Basking Ridge, New Jersey, United States
Memorial Sloan Kettering Monmouth (consent Only)
Middletown, New Jersey, United States
Memorial Sloan Kettering Bergen (consent Only)
Montvale, New Jersey, United States
Memorial Sloan Kettering Commack (consent Only)
Commack, New York, United States
Memorial Sloan Kettering Westchester (consent Only)
Harrison, New York, United States
Memorial Sloan Kettering Cancer Center
New York, New York, United States
Memorial Sloan Kettering Nassau (consent Only)
Uniondale, New York, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 9 Jan 2007
Primary completion: 23 Jan 2026
Completion: 23 Jan 2026
Last update posted: 28 Jan 2026
Registered enrollment: 269
Registry id: NCT00897702

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.