Clinical trialNCT00938470CompletedPhase 2Interventional

Docetaxel, Oxaliplatin, Capecitabine, Fluorouracil, and Radiation Therapy in Treating Patients With Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction

SponsorAlliance for Clinical Trials in OncologyEnrollment73Adenocarcinoma of the Gastroesophageal JunctionEsophageal CancerGastric Cancer

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This randomized phase II trial studies how well docetaxel, oxaliplatin, capecitabine, fluorouracil, and radiation therapy works compared with fluorouracil when given together with oxaliplatin and radiation therapy in treating patients with cancer of the esophagus or gastroesophageal junction that has spread from where it started to nearby tissue or lymph nodes. Drugs used in chemotherapy, such as docetaxel, oxaliplatin, capecitabine, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving more than one drug (combination chemotherapy) together with radiation therapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Steven R. Alberts, MD
Mayo Clinic
Study Chair
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

187 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Mayo Clinic Scottsdale
Scottsdale, Arizona, United States
Front Range Cancer Specialists
Fort Collins, Colorado, United States
Poudre Valley Hospital
Fort Collins, Colorado, United States
Saint Francis/mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
Hartford, Connecticut, United States
Mayo Clinic - Jacksonville
Jacksonville, Florida, United States
Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
Boise, Idaho, United States
Illinois Cancercare - Bloomington
Bloomington, Illinois, United States
St. Joseph Medical Center
Bloomington, Illinois, United States
Graham Hospital
Canton, Illinois, United States
Illinois Cancercare - Canton
Canton, Illinois, United States
Illinois Cancercare - Carthage
Carthage, Illinois, United States
Eureka Community Hospital
Eureka, Illinois, United States
Illinois Cancercare - Eureka
Eureka, Illinois, United States
Galesburg Clinic, Pc
Galesburg, Illinois, United States
Illinois Cancercare - Galesburg
Galesburg, Illinois, United States
Illinois Cancercare - Havana
Havana, Illinois, United States
Mason District Hospital
Havana, Illinois, United States
Illinois Cancercare - Kewanee Clinic
Kewanee, Illinois, United States
Illinois Cancercare - Macomb
Macomb, Illinois, United States
Mcdonough District Hospital
Macomb, Illinois, United States
Trinity Cancer Center at Trinity Medical Center - 7th Street Campus
Moline, Illinois, United States
Facility name not stated
Moline, Illinois, United States
Illinois Cancercare - Monmouth
Monmouth, Illinois, United States
Osf Holy Family Medical Center
Monmouth, Illinois, United States
Bromenn Regional Medical Center
Normal, Illinois, United States
Community Cancer Center
Normal, Illinois, United States
Illinois Cancercare - Community Cancer Center
Normal, Illinois, United States
Community Hospital of Ottawa
Ottawa, Illinois, United States
Oncology Hematology Associates of Central Illinois, Pc - Ottawa
Ottawa, Illinois, United States
Cancer Treatment Center at Pekin Hospital
Pekin, Illinois, United States
Ccop - Illinois Oncology Research Association
Peoria, Illinois, United States
Methodist Medical Center of Illinois
Peoria, Illinois, United States
Osf St. Francis Medical Center
Peoria, Illinois, United States
Oncology Hematology Associates of Central Illinois, Pc - Peoria
Peoria, Illinois, United States
Illinois Cancercare - Peru
Peru, Illinois, United States
Illinois Valley Community Hospital
Peru, Illinois, United States
Illinois Cancercare - Princeton
Princeton, Illinois, United States
Perry Memorial Hospital
Princeton, Illinois, United States
St. Francis Hospital and Health Centers - Beech Grove Campus
Beech Grove, Indiana, United States
Reid Hospital & Health Care Services
Richmond, Indiana, United States

147 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Capecitabine →Docetaxel →Fluorouracil →Oxaliplatin →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Jan 2010
Primary completion: 31 Dec 2013
Completion: 31 Mar 2018
Last update posted: 29 Mar 2018
Registered enrollment: 73
Registry id: NCT00938470

Cross-registrations

Other registry (CTRP (Clinical Trials Reporting SystemNCI-2011-01930Other registry (PDQ (Physician Data QueryCDR0000646724

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.