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Clinical trialNCT00980343CompletedPhase 2Interventional

GDC-0449 in Treating Patients With Recurrent Glioblastoma Multiforme That Can Be Removed by Surgery

SponsorNational Cancer Institute (NCI)Enrollment44Adult Giant Cell GlioblastomaAdult GlioblastomaAdult GliosarcomaRecurrent Adult Brain Tumor
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This randomized phase II trial is studying how well GDC-0449 works in treating patients with recurrent glioblastoma multiforme that can be removed by surgery. GDC-0449 may be effective in treating patients with glioblastoma multiforme.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

9 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • University of California at Los Angeles

    Los Angeles, California, United States

  • University of California San Francisco

    San Francisco, California, United States

  • Emory University/winship Cancer Institute

    Atlanta, Georgia, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, United States

  • Henry Ford Hospital

    Detroit, Michigan, United States

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina, United States

  • Cleveland Clinic Foundation

    Cleveland, Ohio, United States

  • University Hospitals Case Medical Center

    Cleveland, Ohio, United States

  • University of Pennsylvania/abramson Cancer Center

    Philadelphia, Pennsylvania, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Vismodegib →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
28 Feb 2010
Primary completion
31 May 2012
Completion
30 Jun 2012
Last update posted
16 Aug 2017
Registered enrollment
44
Registry id
NCT00980343
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.