Clinical trialNCT00980980CompletedInterventional

Cluster Randomized Trial of Hospitals to Assess Impact of Targeted Versus Universal Strategies to Reduce Methicillin-resistant Staphylococcus Aureus (MRSA) in Intensive Care Units (ICUs)

SponsorHarvard Pilgrim Health CareEnrollment74,256Methicillin-resistant Staphylococcus Aureus

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The Randomized Evaluation of Decolonization versus Universal Clearance to Eliminate MRSA (REDUCE MRSA) Trial is a cluster randomized trial of the comparative effectiveness of three strategies to prevent methicillin-resistant Staphylococcus aureus (MRSA) in intensive care units. The three strategies to be evaluated are: * screening on admission followed by isolation of MRSA+ patients * screening on admission followed by isolation and decolonization of MRSA+ patients * universal decolonization on admission with no screening. The decolonization regimen involves bathing with chlorhexidine plus intra-nasal application of mupirocin. The main outcome will be MRSA+ clinical cultures. The study is a partnership between the CDC, the CDC Prevention Epicenters, and the Hospital Corporation of America.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Edward Septimus, MD
Hospital Corporation of America
Principal Investigator
clinicaltrials.gov ↗
Richard Platt, MD, MS
Department of Population Medicine, Harvard Medical School / Harvard Pilgrim Healthcare Institute
Principal Investigator
clinicaltrials.gov ↗
Susan Huang, MD MPH
University of California, Irvine
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

42 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Alaska Regional
Anchorage, Alaska, United States
Los Robles Hosp & Med Ctr
Thousand Oaks, California, United States
the Medical Center of Aurora
Aurora, Colorado, United States
Blake Medical Center
Brandenton, Florida, United States
Brandon Hospital
Brandon, Florida, United States
Columbia Hosp Corp S Broward (westside)
Fort Lauderdale, Florida, United States
Palms West Hospital
Fort Lauderdale, Florida, United States
Plantation General
Fort Lauderdale, Florida, United States
Regional Med Cr Bayonet Point
Hudson, Florida, United States
Largo Medical Center
Largo, Florida, United States
Community Hospital
New Port Richey, Florida, United States
Orange Park Med Ctr
Orange Park, Florida, United States
Fawcett Memorial Hospital
Port Charlotte, Florida, United States
Doctors Hospital of Sarasota
Sarasota, Florida, United States
South Bay Hospital
Sun City Center, Florida, United States
Capital Regional Med Ctr
Tallahassee, Florida, United States
Coliseum (macon) Northside
Macon, Georgia, United States
Coliseum Medical Center
Macon, Georgia, United States
Cartersville Medical Center
Tucker, Georgia, United States
Eastern Idaho Reg Med Ctr
Idaho Falls, Idaho, United States
Garden Park Medical Center
Gulfport, Mississippi, United States
Lee'S Summit Medical Center
Kansas City, Missouri, United States
Menorah Medical Center
Kansas City, Missouri, United States
Overland Park Regional Hospital
Kansas City, Missouri, United States
Research Belton Hospital
Kansas City, Missouri, United States
Moutainview Medical Center
Las Vegas, Nevada, United States
Parkland Medical Center
Derry, New Hampshire, United States
Oklahoma University Medical Center
Oklahoma City, Oklahoma, United States
Grand Strand Regional Medical Center
Myrtle Beach, South Carolina, United States
Parkridge Medical Center
Chattanooga, Tennessee, United States
Centennial Medical Center
Nashville, Tennessee, United States
Stonecrest
Smyrna, Tennessee, United States
St. David'S Medical Center
Austin, Texas, United States
del Sol Medical Center
El Paso, Texas, United States
Las Palmas Medical Center
El Paso, Texas, United States
Medical Center of Plano
Plano, Texas, United States
Methodist Hospital
San Antonio, Texas, United States
Clear Lake Regional
Webster, Texas, United States
Montgomery Regional Hospital
Blacksburg, Virginia, United States
Columbia Alleghany Regional Hospital
Low Moor, Virginia, United States

2 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Chlorhexidine bath and nasal mupirocin

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Sept 2009
Primary completion: 30 Sept 2011
Completion: 30 Sept 2011
Last update posted: 2 May 2017
Registered enrollment: 74,256
Registry id: NCT00980980

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.