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Clinical trialNCT01000025CompletedPhase 3Interventional

PF-00299804 in Stage IIIB or Stage IV Non-Small Cell Lung Cancer Not Responding to Standard Therapy for Advanced or Metastatic Cancer

SponsorNCIC Clinical Trials GroupEnrollment720Lung Cancer
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: PF-00299804 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known whether PF-00299804 is more effective than a placebo in treating patients with advanced non-small cell lung cancer. PURPOSE: This randomized phase III trial is studying PF-00299804 to see how well it works compared with a placebo in treating patients with stage IIIB or stage IV non-small cell lung cancer that has not responded to standard therapy for advanced or metastatic cancer.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

89 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Argentina
  • Cer - Instituto Medico

    Buenos Aires, B1878dvb Bs. As., Argentina

  • Coiba Centro de Oncologia E Investigacion

    Berazategui, Buenos Aires, Argentina

  • Damic-Fundacion Rusculleda

    Córdoba, Argentina

  • Centro Medico San Roque

    San Miguel de Tucumán, Argentina

Australia
  • Royal Prince Alfred Hospital

    Camperdown, New South Wales, Australia

  • Concord Repatriation General Hospital

    Concord, New South Wales, Australia

  • St. George Hospital, Cancer Care Centre

    Kogarah, New South Wales, Australia

  • Prince of Wales Hospital

    Randwick, New South Wales, Australia

  • Royal North Shore Hospital

    St Leonards, New South Wales, Australia

  • Calvary Mater Newcastle Hospital

    Waratah, New South Wales, Australia

  • Westmead Hospital

    Westmead, New South Wales, Australia

  • the Prince Charles Hospital

    Chermside, Queensland, Australia

  • Nambour General Hospital

    Nambour, Queensland, Australia

  • Royal Adelaide Hospital

    Adelaide, South Australia, Australia

  • Monash Medical Centre

    Clayton, Victoria, Australia

  • Western Hospital

    Footscray, Victoria, Australia

  • Frankston Hospital - Peninsula Oncology Centre

    Frankston, Victoria, Australia

  • Geelong Hospital

    Geelong, Victoria, Australia

  • Austin Hospital

    Heidelberg, Victoria, Australia

  • Sir Charles Gairdner Hospital

    Perth, Western Australia, Australia

Brazil
  • Centro de Oncologia E Radioterapia (cor) Mae de Deus

    Porto Alegre, Rio Grande do Sul, Brazil

  • Fundacao Pio Xii - Hospital de Cancer de Barretos

    Barretos, São Paulo, Brazil

  • Esho - Empresa de Servicos Hospitalares Ltda.

    Brasilia, São Paulo, Brazil

  • Centro de Pesquisa Clinica Do Hospital

    Porto Alegre, São Paulo, Brazil

  • Oxion Hospital Dia Oncologia Ltda - Oxion

    Belo Horizonte, Brazil

  • Facility name not stated

    Centro, Brazil

  • Nucleo de Oncologia Da Bahia

    Salvador, Brazil

  • Gram - Grupo de Assistencia Medica

    São Paulo, Brazil

Canada
  • Cross Cancer Institute

    Edmonton, Alberta, Canada

  • Bcca - Abbotsford Centre

    Abbotsford British Columbia, British Columbia, Canada

  • Bcca - Fraser Valley Cancer Centre

    Surrey, British Columbia, Canada

  • Bcca - Vancouver Cancer Centre

    Vancouver, British Columbia, Canada

  • Atlantic Health Sciences Corporation

    Saint John, New Brunswick, Canada

  • Dr. H. Bliss Murphy Cancer Centre

    St. John's, Newfoundland and Labrador, Canada

  • Qeii Health Sciences Centre

    Halifax, Nova Scotia, Canada

  • Health Sciences North

    Greater Sudbury, Ontario, Canada

  • Juravinski Cancer Centre at Hamilton Health Sciences

    Hamilton, Ontario, Canada

  • Cancer Centre of Southeastern Ontario at Kingston

    Kingston, Ontario, Canada

  • London Regional Cancer Program

    London, Ontario, Canada

  • Lakeridge Health Oshawa

    Oshawa, Ontario, Canada

49 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

PF-00299804Placebo
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
23 Dec 2009
Primary completion
15 Jan 2014
Completion
27 Nov 2015
Last update posted
22 Aug 2023
Registered enrollment
720
Registry id
NCT01000025
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.