Clinical trialNCT01010386CompletedPhase 3Interventional

The Effects of Physiologic Oxygen Tension on Clinical In Vitro Fertilization Outcomes

SponsorYale UniversityEnrollment851InfertilityPregnancy

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Primary Aim * Evaluate whether human embryo exposure to physiologic levels of oxygen during culture improves the percentage of women who deliver a baby following in vitro fertilization and embryo transfer. Hypothesis to be tested: Physiologic oxygen tension during embryo culture, which approximates the oxygen tension in the fallopian tube and uterus, improves live birth rate in clinical In Vitro Fertilization Embryo Transfer (IVF-ET). Secondary Aims Evaluate whether human embryo exposure to physiologic levels of oxygen during culture during in vitro fertilization and embryo transfer * improves embryo cleavage * improves clinical pregnancy rate * reduces multiple pregnancy rate * reduces miscarriage rate Hypothesis to be tested: Physiologic oxygen tension during embryo culture, which approximates the oxygen tension in the fallopian tube and uterus, improves embryo cleavage and clinical pregnancy rates and reduces miscarriage rates in clinical IVF-ET.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Christos Coutifaris, MD, PhD
University of Pennsylvania
Principal Investigator
clinicaltrials.gov ↗
Esther Eisenberg, MD, MPH
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Study Chair
clinicaltrials.gov ↗
John Nulsen, MD
University of Connecticut
Study Director
clinicaltrials.gov ↗
Marcelle Cedars, MD
University of California, San Francisco
Study Director
clinicaltrials.gov ↗
Nanette Santoro, MD
Albert Einstein College of Medicine
Study DirectorKOL profile →
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

4 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of California, San Francisco
San Francisco, California, United States
Yale University
New Haven, Connecticut, United States
University of Connecticut
Storrs, Connecticut, United States
University of Pennsylvania
Philadelphia, Pennsylvania, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Mar 2010
Primary completion: 28 Feb 2014
Completion: 28 Feb 2014
Last update posted: 8 May 2017
Registered enrollment: 851
Registry id: NCT01010386

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.