Clinical trialNCT01013961TerminatedPhase 2Interventional

Rituximab and Alemtuzumab in Treating Older Patients With Progressive Chronic Lymphocytic Leukemia

SponsorECOG-ACRIN Cancer Research GroupEnrollment31Chronic Lymphocytic Leukemia

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Monoclonal antibodies, such as rituximab and alemtuzumab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer killing substances to them. Giving rituximab together with alemtuzumab may kill more cancer cells. PURPOSE: This randomized phase II trial is studying two different doses of rituximab to compare how well they work when given together with alemtuzumab in treating older patients with progressive chronic lymphocytic leukemia.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Clive S. Zent, MD
University of Rochester
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

102 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Mayo Clinic Scottsdale
Scottsdale, Arizona, United States
Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
Fort Lauderdale, Florida, United States
Ella Milbank Foshay Cancer Center at Jupiter Medical Center
Jupiter, Florida, United States
Ccop - Mount Sinai Medical Center
Miami Beach, Florida, United States
Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph'S/candler
Savannah, Georgia, United States
Rush-Copley Cancer Care Center
Aurora, Illinois, United States
Illinois Cancercare - Bloomington
Bloomington, Illinois, United States
St. Joseph Medical Center
Bloomington, Illinois, United States
Graham Hospital
Canton, Illinois, United States
Illinois Cancercare - Canton
Canton, Illinois, United States
Illinois Cancercare - Carthage
Carthage, Illinois, United States
Memorial Hospital
Carthage, Illinois, United States
University of Chicago Cancer Research Center
Chicago, Illinois, United States
Eureka Community Hospital
Eureka, Illinois, United States
Illinois Cancercare - Eureka
Eureka, Illinois, United States
Galesburg Clinic, Pc
Galesburg, Illinois, United States
Illinois Cancercare - Havana
Havana, Illinois, United States
Illinois Cancercare - Kewanee Clinic
Kewanee, Illinois, United States
Illinois Cancercare - Macomb
Macomb, Illinois, United States
Mcdonough District Hospital
Macomb, Illinois, United States
Illinois Cancercare - Monmouth
Monmouth, Illinois, United States
Osf Holy Family Medical Center
Monmouth, Illinois, United States
Bromenn Regional Medical Center
Normal, Illinois, United States
Community Cancer Center
Normal, Illinois, United States
Illinois Cancercare - Community Cancer Center
Normal, Illinois, United States
Community Hospital of Ottawa
Ottawa, Illinois, United States
Oncology Hematology Associates of Central Illinois, Pc - Ottawa
Ottawa, Illinois, United States
Cancer Treatment Center at Pekin Hospital
Pekin, Illinois, United States
Illinois Cancercare - Pekin
Pekin, Illinois, United States
Ccop - Illinois Oncology Research Association
Peoria, Illinois, United States
Methodist Medical Center of Illinois
Peoria, Illinois, United States
Osf St. Francis Medical Center
Peoria, Illinois, United States
Oncology Hematology Associates of Central Illinois, Pc - Peoria
Peoria, Illinois, United States
Proctor Hospital
Peoria, Illinois, United States
Illinois Cancercare - Peru
Peru, Illinois, United States
Illinois Valley Community Hospital
Peru, Illinois, United States
Illinois Cancercare - Princeton
Princeton, Illinois, United States
Swedish-American Regional Cancer Center
Rockford, Illinois, United States
Illinois Cancercare - Spring Valley
Spring Valley, Illinois, United States
Ccop - Carle Cancer Center
Urbana, Illinois, United States

62 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Alemtuzumab →Rituximab →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 27 Apr 2011
Primary completion: 14 Apr 2015
Completion: 14 Apr 2015
Last update posted: 28 Jun 2023
Registered enrollment: 31
Registry id: NCT01013961

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.