Clinical trialNCT01058395CompletedPhase 1/PHASE2Interventional

Safety and Feasibility of Minocycline in the Treatment of Traumatic Brain Injury (TBI)

SponsorWayne State UniversityEnrollment15Traumatic Brain Injury

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is: 1. To assess the safety and feasibility of minocycline administration after TBI in a dose escalation study at two different doses over 7 days. 2. To assess the pharmacokinetic characteristics of two different dosing regimens of minocycline in TBI patients, the effect on biochemical markers of neuroprotective mechanisms, and effect on neurobehavioral and functional outcome. 3. To begin initial assessment of the efficacy of minocycline as a therapeutic agent for severe human TBI.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Allen Lamb, DO
Oakwood Southshore Hospital
Study Director
clinicaltrials.gov ↗
Jay M Meythaler, MD
Wayne State University
Principal Investigator
clinicaltrials.gov ↗
John Fath, MD
Oakwood Hospital Dearborn, Trauma Surgery Director
Principal Investigator
clinicaltrials.gov ↗
Kristina Freese, PA
Wayne State University Dept. PM&R Oakwood
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

2 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Oakwood Dearborn Hospital
Dearborn, Michigan, United States
Oakwood Southshore Hospital
Trenton, Michigan, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Minocycline →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 28 Feb 2010
Primary completion: 30 Sept 2015
Completion: 31 Jan 2016
Last update posted: 17 Sept 2018
Registered enrollment: 15
Registry id: NCT01058395

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 11 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.