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Clinical trialNCT01064817CompletedPhase 2Interventional

PRM-151 in the Prevention of Scarring Following Trabeculectomy

SponsorHoffmann-La RocheEnrollment124Glaucoma
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This study will assess the safety and tolerability of PRM-151 administered as a subconjunctival injection and explore the effect of PRM-151 on various correlates of the wound healing process that occurs in the eye after glaucoma filtration surgery.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

14 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Belgium
  • University Hospital Leuven

    Leuven, Belgium

Czechia
  • Oftalmologicka Klinika Brno-Bohunice

    Brno, Czechia

  • Facility Hospital Hradec Kralove

    Hradec Králové, Czechia

  • Palacky University

    Olomouc, Czechia

  • Hospital Pardubice

    Pardubice, Czechia

  • Charles University

    Prague, Czechia

  • Masaryak'S Hospital

    Ústí nad Labem, Czechia

Netherlands
  • Umc St. Radboud West

    Nijmegen, Netherlands

  • Eramus Medical Center

    Rotterdam, Netherlands

United Kingdom
  • Cheltenham General Hospital

    Gloucestershire, United Kingdom

  • St. Thomas

    London, United Kingdom

  • Norfolk and Norwich University Hospital-Nhs Trust

    Norwich, United Kingdom

  • Oxford Eye Hosiptal

    Oxford, United Kingdom

  • Royal Hallamshire Hospital

    Sheffield, United Kingdom

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

PRM-151Placebo
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
14 Jun 2010
Primary completion
30 Apr 2012
Completion
14 Nov 2012
Last update posted
28 Apr 2022
Registered enrollment
124
Registry id
NCT01064817

Cross-registrations

EU-CTR / CTIS (EudraCT)2009-017859-98
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.