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Clinical trialNCT01083667CompletedPhase 1/PHASE2Interventional

SOD1 Inhibition by Pyrimethamine in Familial Amyotrophic Lateral Sclerosis (ALS)

SponsorWeill Medical College of Cornell UniversityEnrollment32Familial Amyotrophic Lateral Sclerosis
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The objective of this study will be to evaluate the safety, tolerability and effect on SOD1 levels by pyrimethamine in patients with familial amyotrophic lateral sclerosis.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

  • Dale J. Lange, M.D.

    Hospital for Special Surgery/Weill Cornell Medical Center

    Principal Investigator

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

5 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Germany
  • Universitäts- Und Rehabilitationskliniken Ulm

    Ulm, Germany

Italy
  • Milano Neurological Institute

    Milan, Italy

Sweden
  • Umea University

    Umeå, Sweden

United States
  • Weill Cornell Medical Center/new York Presbyterian Hospital

    New York, New York, United States

  • Methodist Neurological Institute

    Houston, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
30 Nov 2009
Primary completion
31 Dec 2014
Completion
31 May 2016
Last update posted
19 Jun 2017
Registered enrollment
32
Registry id
NCT01083667

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.