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Clinical trialNCT01088763TerminatedPhase 1Interventional

Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia

SponsorNational Cancer Institute (NCI)Enrollment129Childhood Atypical Teratoid/Rhabdoid TumorChildhood Central Nervous System ChoriocarcinomaChildhood Central Nervous System GerminomaChildhood Central Nervous System Mixed Germ Cell TumorChildhood Central Nervous System TeratomaChildhood Central Nervous System Yolk Sac Tumor+40 more conditions
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase I/II clinical trial is studying the side effects and best dose of gamma-secretase inhibitor RO4929097 and to see how well it works in treating young patients with relapsed or refractory solid tumors, CNS tumors, lymphoma, or T-cell leukemia. Gamma-secretase inhibitor RO4929097 may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

12 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada
  • Hospital for Sick Children

    Toronto, Ontario, Canada

United States
  • Lucile Packard Children'S Hospital Stanford University

    Palo Alto, California, United States

  • Stanford University Hospitals and Clinics

    Stanford, California, United States

  • Lurie Children'S Hospital-Chicago

    Chicago, Illinois, United States

  • Indiana University Medical Center

    Indianapolis, Indiana, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, United States

  • Washington University School of Medicine

    St Louis, Missouri, United States

  • Columbia University Medical Center

    New York, New York, United States

  • Nationwide Children'S Hospital

    Columbus, Ohio, United States

  • St. Jude Children'S Research Hospital

    Memphis, Tennessee, United States

  • Baylor College of Medicine

    Houston, Texas, United States

  • Seattle Children'S Hospital

    Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Dexamethasone →Gamma-secretase/Notch signalling pathway inhibitor RO4929097
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Mar 2010
Primary completion
31 May 2011
Completion
31 May 2011
Last update posted
5 Nov 2014
Registered enrollment
129
Registry id
NCT01088763
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.