Clinical trialNCT01116271CompletedPhase 2Interventional

Study of Selumetinib (AZD6244)(ARRY-142886) in Combination With Irinotecan in Previously Treated Patients With Colorec

SponsorAstraZenecaEnrollment32Colorectal Cancer

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to determine whether treatment with Selumetinib (AZD6244) (Hyd-Sulfate) in combination with Irinotecan as a second treatment in patients with K-ras or B-raf mutation will prevent tumor progression and prolong progression free survival.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Howard Hochster, MD
Yale University
Principal Investigator
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Lawrence Leichman, MD
Desert Regional Comprehensive Cancer Center
Principal Investigator
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

12 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Research Site
Los Angeles, California, United States
Research Site
Palm Springs, California, United States
Research Site
Aurora, Colorado, United States
Research Site
New Haven, Connecticut, United States
Research Site
Newark, Delaware, United States
Research Site
Miami Beach, Florida, United States
Research Site
New York, New York, United States
Reserach Site
Chapel Hill, North Carolina, United States
Research Site
Greenville, North Carolina, United States
Research Site
Washington, North Carolina, United States
Research Site
Philadelphia, Pennsylvania, United States
Research Site
Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Selumetinib →Irinotecan →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Apr 2010
Primary completion: 31 Jul 2012
Completion: 31 Jul 2012
Last update posted: 14 Jan 2013
Registered enrollment: 32
Registry id: NCT01116271

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.