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Clinical trialNCT01120275TerminatedPhase 2Interventional

Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV Melanoma

SponsorNational Cancer Institute (NCI)Enrollment36Acral Lentiginous Malignant MelanomaLentigo Maligna Malignant MelanomaNodular Malignant MelanomaRecurrent MelanomaSolar Radiation-related Skin MelanomaStage IV Melanoma+1 more conditions
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II trial is studying how well gamma-secretase/Notch signalling pathway inhibitor RO4929097 works in treating patients with stage IV melanoma. Gamma-secretase/Notch signalling pathway inhibitor RO4929097 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

178 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Providence Hospital

    Mobile, Alabama, United States

  • Fairbanks Memorial Hospital

    Fairbanks, Alaska, United States

  • University of Arizona Health Sciences Center

    Tucson, Arizona, United States

  • Saint Edward Mercy Medical Center

    Fort Smith, Arkansas, United States

  • University of Arkansas for Medical Sciences

    Little Rock, Arkansas, United States

  • Loma Linda University Medical Center

    Loma Linda, California, United States

  • Fremont - Rideout Cancer Center

    Marysville, California, United States

  • University of California Medical Center at Irvine-Orange Campus

    Orange, California, United States

  • University of California at Davis Cancer Center

    Sacramento, California, United States

  • Tahoe Forest Cancer Center

    Truckee, California, United States

  • University of Colorado Cancer Center - Anschutz Cancer Pavilion

    Aurora, Colorado, United States

  • Denver Veterans Administration Medical Center

    Denver, Colorado, United States

  • Poudre Valley Hospital

    Fort Collins, Colorado, United States

  • Saint Mary'S Hospital and Regional Medical Center

    Grand Junction, Colorado, United States

  • Saint Francis Hospital and Medical Center

    Hartford, Connecticut, United States

  • Northeast Georgia Medical Center

    Gainesville, Georgia, United States

  • Kapiolani Medical Center for Women and Children

    Honolulu, Hawaii, United States

  • Oncare Hawaii Inc-Kuakini

    Honolulu, Hawaii, United States

  • Oncare Hawaii Inc-Pob Ii

    Honolulu, Hawaii, United States

  • Queen'S Medical Center

    Honolulu, Hawaii, United States

  • Straub Clinic and Hospital

    Honolulu, Hawaii, United States

  • the Cancer Center of Hawaii-Liliha

    Honolulu, Hawaii, United States

  • University of Hawaii

    Honolulu, Hawaii, United States

  • Castle Medical Center

    Kailua, Hawaii, United States

  • Wilcox Memorial Hospital and Kauai Medical Clinic

    Lihue, Hawaii, United States

  • Maui Memorial Medical Center

    Wailuku, Hawaii, United States

  • Pali Momi Medical Center

    ‘Aiea, Hawaii, United States

  • Saint Anthony'S Health

    Alton, Illinois, United States

  • University of Chicago

    Chicago, Illinois, United States

  • Decatur Memorial Hospital

    Decatur, Illinois, United States

  • Loyola University Medical Center

    Maywood, Illinois, United States

  • Good Samaritan Regional Health Center

    Mount Vernon, Illinois, United States

  • Memorial Medical Center

    Springfield, Illinois, United States

  • Saint Francis Hospital and Health Centers

    Beech Grove, Indiana, United States

  • Reid Hospital and Health Care Services

    Richmond, Indiana, United States

  • Genesis Medical Center - East Campus

    Davenport, Iowa, United States

  • Hays Medical Center

    Hays, Kansas, United States

  • Promise Regional Medical Center-Hutchinson

    Hutchinson, Kansas, United States

  • University of Kansas Medical Center

    Kansas City, Kansas, United States

  • Lawrence Memorial Hospital

    Lawrence, Kansas, United States

138 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Gamma-secretase/Notch signalling pathway inhibitor RO4929097
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Oct 2010
Primary completion
31 May 2013
Completion
31 Aug 2015
Last update posted
14 Jun 2016
Registered enrollment
36
Registry id
NCT01120275

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.