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Clinical trialNCT01137968CompletedPhase 2Interventional

Imetelstat as Maintenance Therapy After Initial Induction Chemotherapy in Non-small Cell Lung Cancer (NSCLC)

SponsorGeron CorporationEnrollment116Non-small Cell Lung Cancer
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this is to evaluate the efficacy and safety of imetelstat (GRN163L) as maintenance therapy for patients with advanced stage NSCLC who have not progressed after 4 cycles of platinum based therapy. Participants will be randomized in a 2:1 ratio to imetelstat + standard of care versus standard of care alone. Participants who received bevacizumab with their induction chemotherapy will continue to receive bevacizumab on this study.

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

33 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada
  • Hôpital Charles Lemoyne

    Greenfield Park, Quebec, Canada

  • Hospital Notre-Dame

    Montreal, Quebec, Canada

Germany
  • Krankenhaus Nordwest

    Frankfurt, Frankfurt, Germany

  • Krankenhaus Grosshansdorf

    Grosshansdorf, Free and Hanseatic City of Hamburg, Germany

  • Universitaetsklinikum Mainz

    Mainz, Mainz, Germany

  • Asklepios Klinik Gauting Gmbh

    Gauting, Munich, Germany

  • Klinikum Rechts Der Isar Der Tu München

    München, Munich, Germany

United States
  • Achieve Clinical Research, Llc

    Birmingham, Alabama, United States

  • Clearview Cancer Institute

    Huntsville, Alabama, United States

  • Pacific Cancer Medical Center, Inc.

    Anaheim, California, United States

  • Cancer Care Associates of Fresno Medical Group Inc

    Fresno, California, United States

  • St. Joseph'S Hospital

    Orange, California, United States

  • Kaiser Permanente Medical Center

    Vallejo, California, United States

  • University of Colorado Denver School of Medicine

    Aurora, Colorado, United States

  • Florida Cancer Specialists

    Fort Myers, Florida, United States

  • Integrated Community Oncology Network

    Jacksonville, Florida, United States

  • H. Moffitt Lee Cancer Center

    Tampa, Florida, United States

  • Ingalls Memorial Hospital

    Harvey, Illinois, United States

  • Cancer Center of Kansas

    Wichita, Kansas, United States

  • Montgomery Cancer Center

    Mount Sterling, Kentucky, United States

  • Auerbach Hematology Oncology

    Baltimore, Maryland, United States

  • Karmanos Cancer Institute

    Detroit, Michigan, United States

  • Hematology Oncology Centers

    Billings, Montana, United States

  • Blumenthal Cancer Center

    Charlotte, North Carolina, United States

  • Kaiser Northwest

    Portland, Oregon, United States

  • South Carolina Oncology Associates

    Columbia, South Carolina, United States

  • the Jones Clinic

    Germantown, Tennessee, United States

  • Sarah Cannon Research Institute

    Nashville, Tennessee, United States

  • Ut Southwestern Medical Center

    Dallas, Texas, United States

  • Scott and White Memorial Hospital (texas A & M)

    Temple, Texas, United States

  • Swedish Cancer Institute

    Seattle, Washington, United States

  • Northwest Medical Specialties

    Tacoma, Washington, United States

  • University of Wisconsin

    Madison, Wisconsin, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 May 2010
Primary completion
30 Sept 2013
Completion
30 Sept 2013
Last update posted
26 Jan 2016
Registered enrollment
116
Registry id
NCT01137968

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.