Clinical trialNCT01163747CompletedPhase 4Interventional

A Study of the Effects of RoActemra/Actemra on Vaccination in Patients With Rheumatoid Arthritis on Background Methotrexate (VISARA)

SponsorGenentech, Inc.Enrollment91Rheumatoid Arthritis

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This randomized, parallel-group, open-label study will evaluate the effect of Actemra (tocilizumab) on vaccination in patients with active rheumatoid arthritis who have an inadequate response to methotrexate and who have had an inadequate clinical response or were intolerant to treatment with one or more anti-tumor necrosis factor (anti-TNF) therapies.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Micki Klearman, M.D.
Genentech, Inc.
Study DirectorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

47 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Facility name not stated
Anniston, Alabama, United States
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Birmingham, Alabama, United States
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Huntsville, Alabama, United States
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Glendale, Arizona, United States
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Mesa, Arizona, United States
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Paradise Valley, Arizona, United States
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Paradise Valley, Arizona, United States
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Scottsdale, Arizona, United States
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Jonesboro, Arkansas, United States
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Fullerton, California, United States
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Hemet, California, United States
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San Leandro, California, United States
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Santa Maria, California, United States
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Upland, California, United States
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Bridgeport, Connecticut, United States
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Melbourne, Florida, United States
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South Miami, Florida, United States
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Tavares, Florida, United States
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Boise, Idaho, United States
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Idaho Falls, Idaho, United States
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Maywood, Illinois, United States
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Vernon Hills, Illinois, United States
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South Bend, Indiana, United States
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Baltimore, Maryland, United States
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Baltimore, Maryland, United States
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Saint Clair Shores, Michigan, United States
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Tupelo, Mississippi, United States
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Las Vegas, Nevada, United States
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Manalapan, New Jersey, United States
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Albany, New York, United States
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Belmont, North Carolina, United States
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Charlotte, North Carolina, United States
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Greenville, North Carolina, United States
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Cleveland, Ohio, United States
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Gallipolis, Ohio, United States
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Middleburg Heights, Ohio, United States
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Lake Oswego, Oregon, United States
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Duncansville, Pennsylvania, United States
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Philadelphia, Pennsylvania, United States
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Wexford, Pennsylvania, United States

7 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Pneumococcal 23-valent polysaccharide vaccineTetanus Toxoid Adsorbed VaccineMethotrexate →Tocilizumab →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Sept 2010
Primary completion: 31 Dec 2011
Completion: 30 Jun 2012
Last update posted: 7 Dec 2012
Registered enrollment: 91
Registry id: NCT01163747

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.