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Clinical trialNCT01164163CompletedPhase 1Interventional

INCB18424 in Treating Young Patients With Relapsed or Refractory Solid Tumor, Leukemia, or Myeloproliferative Disease

SponsorChildren's Oncology GroupEnrollment49Chronic Myeloproliferative DisordersLeukemiaMyelodysplastic SyndromesMyelodysplastic/Myeloproliferative NeoplasmsUnspecified Childhood Solid Tumor, Protocol Specific
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: INCB18424 (Ruxolitinib) may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase 1 clinical trial is studying the side effects and best dose of INCB18424 in treating young patients with relapsed or refractory solid tumor, leukemia, or myeloproliferative disease.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

24 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Uab Comprehensive Cancer Center

    Birmingham, Alabama, United States

  • Children'S Hospital of Orange County

    Orange, California, United States

  • Ucsf Helen Diller Family Comprehensive Cancer Center

    San Francisco, California, United States

  • Children'S Hospital Colorado Center for Cancer and Blood Disorders

    Aurora, Colorado, United States

  • Children'S National Medical Center

    Washington D.C., District of Columbia, United States

  • Aflac Cancer Center and Blood Disorders Service of Children'S Healthcare of Atlanta - Egleston Campus

    Atlanta, Georgia, United States

  • Children'S Memorial Hospital - Chicago

    Chicago, Illinois, United States

  • Riley'S Children Cancer Center at Riley Hospital for Children

    Indianapolis, Indiana, United States

  • Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

    Baltimore, Maryland, United States

  • Warren Grant Magnuson Clinical Center - Nci Clinical Trials Referral Office

    Bethesda, Maryland, United States

  • Dana-Farber/harvard Cancer Center at Dana-Farber Cancer Institute

    Boston, Massachusetts, United States

  • C.S. Mott Children'S Hospital at University of Michigan Medical Center

    Ann Arbor, Michigan, United States

  • Masonic Cancer Center at University of Minnesota

    Minneapolis, Minnesota, United States

  • Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis

    St Louis, Missouri, United States

  • Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center

    New York, New York, United States

  • Cincinnati Children'S Hospital Medical Center

    Cincinnati, Ohio, United States

  • Knight Cancer Institute at Oregon Health and Science University

    Portland, Oregon, United States

  • Children'S Hospital of Philadelphia

    Philadelphia, Pennsylvania, United States

  • Children'S Hospital of Pittsburgh of Upmc

    Pittsburgh, Pennsylvania, United States

  • St. Jude Children'S Research Hospital

    Memphis, Tennessee, United States

  • Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas

    Dallas, Texas, United States

  • Baylor University Medical Center - Houston

    Houston, Texas, United States

  • Children'S Hospital and Regional Medical Center - Seattle

    Seattle, Washington, United States

  • Midwest Children'S Cancer Center at Children'S Hospital of Wisconsin

    Milwaukee, Wisconsin, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Ruxolitinib
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
30 Sept 2010
Primary completion
31 Oct 2014
Completion
—
Last update posted
23 Oct 2014
Registered enrollment
49
Registry id
NCT01164163

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.