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Clinical trialNCT01178320CompletedObservational

Carotid Plaque Characteristics by MRI in AIM-HIGH (Carotid MRI Substudy)

SponsorUniversity of WashingtonEnrollment230AtherosclerosisCarotid Artery DiseasesCoronary Artery Disease
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Heart attacks and strokes caused by the unstable atherosclerotic plaques remain the leading cause of death in the United States. Unstable plaques often have more fat than stable plaques. This study will investigate if a treatment with LDL-lowering plus HDL-raising compared with LDL-lowering alone would more effectively reduce the plaque fat content assessed by magnetic resonance imaging (MRI), therefore, further reducing heart attacks and strokes.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

19 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada
  • Heart Health Institute

    Calgary, Alberta, Canada

  • University of Calgary

    Calgary, Alberta, Canada

  • Vancouver General Hospital

    Vancouver, British Columbia, Canada

  • University of Western Ontario

    London, Ontario, Canada

United States
  • Cardiovascular Consultants

    Phoenix, Arizona, United States

  • Long Beach Va Medical Center

    Long Beach, California, United States

  • University of Southern California

    Los Angeles, California, United States

  • Johns Hopkins University

    Baltimore, Maryland, United States

  • University of Maryland

    Baltimore, Maryland, United States

  • Mayo Clinic

    Rochester, Minnesota, United States

  • Duke University

    Durham, North Carolina, United States

  • Wake Forest University

    Winston-Salem, North Carolina, United States

  • Philadelphia Va Medical Center

    Philadelphia, Pennsylvania, United States

  • Baylor College of Medicine

    Houston, Texas, United States

  • Kelsey Research Foundation

    Houston, Texas, United States

  • Methodist Hospital

    Houston, Texas, United States

  • Harborview Medical Center

    Seattle, Washington, United States

  • Puget Sound Va Medical Center, Seattle Campus

    Seattle, Washington, United States

  • University of Washington

    Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Simvastatin →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Mar 2008
Primary completion
30 Apr 2013
Completion
28 Feb 2015
Last update posted
9 Feb 2018
Registered enrollment
230
Registry id
NCT01178320
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.