Clinical trialNCT01182766CompletedPhase 2/PHASE3Interventional

New Treatment for Alcohol and Nicotine Dependence

SponsorUniversity of VirginiaEnrollment236Alcohol DependenceNicotine Dependence

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This research study aims to test whether topiramate (a drug that is being used for seizure) will help individuals who have problems with both alcohol and nicotine. The investigators believe that individuals taking topiramate will be more successful at abstaining from both alcohol and nicotine than individuals taking placebo.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Bankole A Johnson, MD
University of Virginia
Principal Investigator
clinicaltrials.gov ↗
Nassima Ait-Daoud Tiouririne, MD
University of Virginia
Principal Investigator
clinicaltrials.gov ↗
Paul M Cinciripini, PHD
M.D. Anderson Cancer Center
Principal Investigator
clinicaltrials.gov ↗
Robert M Anthenelli, MD
University of California, San Diego
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

4 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of California, San Diego
La Jolla, California, United States
University of Texas Md Anderson Cancer Center
Houston, Texas, United States
University of Virginia Center for Addiction Research & Education
Charlottesville, Virginia, United States
University of Virginia Center for Addiction Research & Education
Richmond, Virginia, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

High-Dose TopiramateLow-Dose TopiramatePlacebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 1 Nov 2011
Primary completion: 6 Oct 2017
Completion: 6 Oct 2017
Last update posted: 31 Oct 2025
Registered enrollment: 236
Registry id: NCT01182766

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.