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Clinical trialNCT01186328TerminatedPhase 1Interventional

EZN-3042 Administered With Re-induction Chemotherapy in Children With Relapsed Acute Lymphoblastic Leukemia (ALL)

SponsorTherapeutic Advances in Childhood Leukemia ConsortiumEnrollment6Leukemia, Lymphoblastic, AcuteLeukemia, Lymphoblastic, Acute, T CellLymphoblastic Leukemia, AcuteLymphoblastic Leukemia, Acute, Childhood
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

An experimental drug called EZN-3042 targets survivin, a protein expressed in leukemia cells at relapse that promotes the leukemia cells to grow. The main goal of this phase I study is to find out the dose of EZN-3042 that can be safely given without serious side effects both alone and in combination with standard chemotherapy drugs during re-induction.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

7 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia
  • Sydney Children'S Hospital

    Sydney, Australia

United States
  • Childrens Hospital Los Angeles

    Los Angeles, California, United States

  • Johns Hopkins University

    Baltimore, Maryland, United States

  • Childrens Hospital & Clinics of Minnesota

    Minneapolis, Minnesota, United States

  • University of Minnesota Children'S Hospital

    Minneapolis, Minnesota, United States

  • New York University Medical Center

    New York, New York, United States

  • St. Jude

    Memphis, Tennessee, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Cytarabine →Doxorubicin →EZN-3042Hydrocortisone / lactate →Methotrexate →Pegaspargase →Prednisone →Vincristine →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
24 Aug 2010
Primary completion
10 Jan 2012
Completion
10 Jan 2012
Last update posted
1 Feb 2024
Registered enrollment
6
Registry id
NCT01186328
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.