FindMyKOL
Clinical trialNCT01189253TerminatedPhase 2/PHASE3Interventional

Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma

SponsorEuropean Organisation for Research and Treatment of Cancer - EORTCEnrollment133Sarcoma
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Drugs used in chemotherapy, such as doxorubicin hydrochloride and trabectedin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether trabectedin is more effective than doxorubicin hydrochloride in treating patients with advanced or metastatic soft tissue sarcoma. PURPOSE: This randomized phase II/III trial is studying the safety of trabectedin compared with doxorubicin hydrochloride and to see how well they work in treating patients with advanced or metastatic soft tissue sarcoma.

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

43 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Austria
  • Medical University Vienna

    Vienna, Austria

Belgium
  • Cliniques Universitaires St. Luc

    Brussels, Belgium

  • Hôpitaux Universitaires Bordet-Erasme - Institut Jules Bordet

    Brussels, Belgium

  • U.Z. Gasthuisberg

    Leuven, Belgium

Denmark
  • Aarhus University Hospital

    Aarhus, Denmark

  • Herlev Hospital - University Copenhagen

    Herlev, Denmark

France
  • Institut Bergonie

    Bordeaux, France

  • Centre Georges-Francois-Leclerc

    Dijon, France

  • Centre Oscar Lambret

    Lille, France

  • Centre Leon Berard

    Lyon, France

  • Assistance Publique - Hôpitaux de Marseille - Hôpital de la Timone

    Marseille, France

  • Institut de Cancerologie de L'Ouest (ico) - Centre Rene Gauducheau

    Nantes - Saint Herblain, France

  • Institut Curie

    Paris, France

  • Institut Gustave Roussy

    Villejuif, France

Germany
  • Helios Klinikum Bad Saarow

    Bad Saarow, Germany

  • Universitaetsklinikum Koeln

    Cologne, Germany

  • Universitaetsklinikum Carl Gustav Carus

    Dresden, Germany

  • Universitaets-Krankenhaus Eppendorf

    Hamburg, Germany

  • Medizinische Hochschule Hannover

    Hanover, Germany

  • Universitaetsmedizin Mannheim

    Mannheim, Germany

  • Klinikum Grosshadern Ludwig-Maximilians Univ. Muenchen

    München, Germany

Hungary
  • Military Hospital - State Health Centre

    Budapest, Hungary

Netherlands
  • the Netherlands Cancer Institute-Antoni Van Leeuwenhoekziekenhuis

    Amsterdam, Netherlands

  • University Medical Center Groningen

    Groningen, Netherlands

  • Leiden University Medical Centre

    Leiden, Netherlands

  • Radboud University Nijmegen Medical Centre

    Nijmegen, Netherlands

  • Erasmus Mc - Daniel Den Hoed Cancer Center

    Rotterdam, Netherlands

Poland
  • Maria Sklodowska-Curie Memorial Cancer Centre

    Warsaw, Poland

Slovakia
  • National Cancer Institute

    Bratislava, Slovakia

Spain
  • Hospital General Vall D'Hebron

    Barcelona, Spain

  • Hospital Universitario San Carlos

    Madrid, Spain

Switzerland
  • Centre Hospitalier Universitaire Vaudois

    Lausanne, Switzerland

United Kingdom
  • Nhs Greater Glasgow and Clyde - Beatson West of Scotland Cancer Centre

    Glasgow, United Kingdom

  • Christie Nhs Foundation Trust

    Manchester, United Kingdom

  • Nottingham University Hospitals Nhs Trust - City Hospital Campus

    Nottingham, United Kingdom

United States
  • Sarcoma Oncology Center

    Santa Monica, California, United States

  • Stanford Hospital and Clinics

    Stanford, California, United States

  • Holden Comprehensive Cancer Center at University of Iowa

    Iowa City, Iowa, United States

  • Dana Farber Institute

    Boston, Massachusetts, United States

  • Massachussets General Hospital

    Boston, Massachusetts, United States

3 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 May 2011
Primary completion
30 Jun 2013
Completion
30 Jun 2015
Last update posted
8 Aug 2014
Registered enrollment
133
Registry id
NCT01189253

Cross-registrations

EU-CTR / CTIS (EudraCT)2009-014889-26

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.