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Clinical trialNCT01189864TerminatedObservational

Cross-linking of Corneal Collagen (CXL) With Ultraviolet-A in Asymmetric Corneas

SponsorCxlusaEnrollment3,493DegenerationEctasiaKeratoconus
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) as a method to increase the biomechanical and biochemical stability of the cornea by inducing additional cross-links within or between collagen fibers using UVA light and the photo- mediator riboflavin. The purpose of this study is to generate data for presentation at medical meetings and for peer-review publication. The data generated by this study will not be submitted to the FDA to support commercialization of these riboflavin drops.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

16 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Schwartz Laser Eye Center

    Scottsdale, Arizona, United States

  • Harvard Eye Associates

    Laguna Hills, California, United States

  • Clear View Eye & Laser Medical Center

    San Diego, California, United States

  • Facility name not stated

    San Francisco, California, United States

  • Davidorf Eye Group

    West Hills, California, United States

  • Corneal Consultants of Colorado, P.C

    Littleton, Colorado, United States

  • the Center for Excellence in Eye Care

    Miami, Florida, United States

  • Chicago Cornea Consultants, Ltd

    Hoffman Estates, Illinois, United States

  • Tlc Laser Eye Center

    Rockville, Maryland, United States

  • Talamo Laser Eye Center

    Waltham, Massachusetts, United States

  • Ophthalomology Associates

    St Louis, Missouri, United States

  • South Shore Eye Care Llp

    Wantagh, New York, United States

  • Cleveland Eye Clinic

    Brecksville, Ohio, United States

  • Tlc Laser Eye Center

    Fairfax, Virginia, United States

  • Northwest Eye Surgeons

    Seattle, Washington, United States

  • Empire Eye Physicians

    Spokane Valley, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Ciprofloxicin or Vigamox or otherNonsteroidalSteroid
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
1 Feb 2010
Primary completion
3 Feb 2017
Completion
3 Feb 2017
Last update posted
12 Oct 2018
Registered enrollment
3,493
Registry id
NCT01189864

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.