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Clinical trialNCT01196429CompletedPhase 2Interventional

Temsirolimus, Carboplatin, and Paclitaxel as First-Line Therapy in Treating Patients With Newly Diagnosed Stage III-IV Clear Cell Ovarian Cancer

SponsorNational Cancer Institute (NCI)Enrollment90Ovarian Clear Cell CystadenocarcinomaStage III Ovarian CancerStage IV Ovarian Cancer
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II trial studies how well temsirolimus, carboplatin, and paclitaxel as first-line therapy works in treating patients with newly diagnosed stage III-IV clear cell ovarian cancer. Temsirolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as carboplatin and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving temsirolimus with combination chemotherapy may be an effective treatment for ovarian cancer.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

145 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Japan
  • Tohoku University School of Medicine

    Sendai, Aoba-ku, Japan

  • Kure National Hospital

    Kure, Hiroshima, Japan

  • Hokkaido University Hospital

    Sapporo, Hokkaido, Japan

  • Hyogo Cancer Center

    Akashi, Hyōgo, Japan

  • Iwate Medical University School of Medicine

    Morioka, Iwate, Japan

  • Kagoshima City Hospital

    Kagoshima, Kagoshima-ken, Japan

  • Niigata University Medical and Dental Hospital

    Niigata, Niigata, Japan

  • University of the Ryukyus Hospital-Col Health Scnc

    Nakagami-gun, Okinawa, Japan

  • Shizuoka Cancer Center

    Shizuoka, Suntou, Japan

  • Keio University

    Shinjuku-ku, Tokyo, Japan

  • Shikoku Cancer Center

    Matsuyama, Japan

  • National Kyushu Cancer Center

    Minamiku, Japan

  • Jikei University School of Medicine

    Minato-ku, Tokyo, Japan

  • Kinki University

    Osaka, Osaka, Japan

  • Saitama Medical University International Medical Center

    Saitama, Japan

  • National Cancer Center Hospital

    Tokyo, Japan

  • Tottori University

    Tottori, Japan

South Korea
  • Keimyung University-Dongsan Medical Center

    Jung-Ku, Daegu, South Korea

  • National Cancer Center-Korea

    Goyang-si, Gyeonggi-do, South Korea

  • Samsung Medical Center

    Seoul, Korea, South Korea

  • Asan Medical Center

    Seoul, South Korea

  • Gangnam Severance Hospital

    Seoul, South Korea

  • Korea Cancer Center Hospital

    Seoul, South Korea

  • Seoul National University Hospital

    Seoul, South Korea

United States
  • Saint Joseph'S Hospital and Medical Center

    Phoenix, Arizona, United States

  • Providence Saint Joseph Medical Center/disney Family Cancer Center

    Burbank, California, United States

  • Los Angeles County-Usc Medical Center

    Los Angeles, California, United States

  • Usc / Norris Comprehensive Cancer Center

    Los Angeles, California, United States

  • Palo Alto Medical Foundation-Gynecologic Oncology

    Mountain View, California, United States

  • University of Colorado Cancer Center - Anschutz Cancer Pavilion

    Aurora, Colorado, United States

  • Hartford Hospital

    Hartford, Connecticut, United States

  • Saint Francis Hospital and Medical Center

    Hartford, Connecticut, United States

  • the Hospital of Central Connecticut

    New Britain, Connecticut, United States

  • Florida Hospital Orlando

    Orlando, Florida, United States

  • Memorial University Medical Center

    Savannah, Georgia, United States

  • Saint Alphonsus Cancer Care Center-Boise

    Boise, Idaho, United States

  • Northwestern University

    Chicago, Illinois, United States

  • Rush University Medical Center

    Chicago, Illinois, United States

  • University of Chicago Comprehensive Cancer Center

    Chicago, Illinois, United States

  • Sudarshan K Sharma Md Limted-Gynecologic Oncology

    Hinsdale, Illinois, United States

105 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Aug 2010
Primary completion
31 Jan 2015
Completion
31 Jan 2015
Last update posted
8 Aug 2019
Registered enrollment
90
Registry id
NCT01196429

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.