Clinical trialNCT01227967CompletedPhase 2Interventional

Comparing the Efficacy, Safety, and Tolerability of Combination Antivirals (Amantadine, Ribavirin, Oseltamivir) Versus Oseltamivir for the Treatment of Influenza in Adults at Risk for Complications

SponsorNational Institute of Allergy and Infectious Diseases (NIAID)Enrollment881Influenza

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Seasonal influenza is responsible for many hospitalizations and deaths each year, despite effective antiviral treatments. Some individuals have medical conditions such as heart or lung diseases that make them particularly at risk of severe influenza infections that may result in hospitalization or death. Oseltamivir (Tamiflu) is used most often to treat flu, but there are still many hospitalizations, complications, and deaths even with treatment. This study evaluated the use of combination antivirals (amantadine, oseltamivir, and ribavirin) compared to oseltamivir alone in the treatment of influenza in an at-risk population.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

John Beigel, MD
Leidos Biomedical Research, Inc. in support of Clinical Research Section, LIR, NIAID, Natinal Institutes of Health
Study Chair
clinicaltrials.gov ↗
John Treanor, MD
University of Rochester
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

91 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Argentina

Instituto Medico Platense
La Plata, Buenos Aires, Argentina
Hospital Houssay
Vicente López, Buenos Aires, Argentina
Centro de Educación Médica E Investigaciónes Clínicas (cemic)
Buenos Aires, Argentina
Fundación del Centro de Estudios Infectológicos (funcei)
Buenos Aires, Argentina
Hospital General de Agudos J. M. Ramos Mejía
Buenos Aires, Argentina
Hospital Italiano de Buenos Aires
Buenos Aires, Argentina
Hospital Rawson
Córdoba, Argentina
Instituto Centralizado de Asistencia E Investigación Clínica Integral (caici)
Santa Fe, Argentina

Australia

Holdsworth House Med Practice
Darlinghurst, New South Wales, Australia
Taylor Square Private Clinic
Darlinghurst, New South Wales, Australia
Westmead Hospital
Westmead, New South Wales, Australia
Royal Brisbane
Herston, Queensland, Australia
Northside Clinic
Fitzroy North, Victoria, Australia
the Alfred Hospital
Melbourne, Victoria, Australia
Royal Melbourne Hospital
Parkville, Victoria, Australia

Mexico

Instituto Nacional de Ciencias Médicas Y Nutrición (incmn) Salvador Zubirán
México, Mexico
Hospital General Y de Alta Especialidad "dr. Manuel Gea Gonzalez"
Tlalpan, Mexico
Instituto Nacional de Enfermedades Respiratorias (iner)
Tlalpan, Mexico

Thailand

Siriraj Hospital, Mahidol University
Bangkoknoi, Bangkok, Thailand
Hiv-Nat, the Thai Red Cross Aids
Patumwan, Bangkok, Thailand
Srinagarind Hospital, Khon Kaen University
Muang, Changwat Khon Kaen, Thailand
Bamrasnaradura Infectious Diseases Institute
Muang, Changwat Nonthaburi, Thailand

United States

Simon Williamson Clinic
Birmingham, Alabama, United States
East Valley Family Physicians
Chandler, Arizona, United States
Thomas Lenzmeier Family Practice
Glendale, Arizona, United States
Central Phoenix Medical Center
Phoenix, Arizona, United States
Wcct Global Llc
Costa Mesa, California, United States
Advanced Rx Clinical Research
Garden Grove, California, United States
Torrance Clinical Research Institute, Inc.
Lomita, California, United States
University of Southern California
Los Angeles, California, United States
University of California at San Diego
San Diego, California, United States
Westlake Medical Research (ca)
Thousand Oaks, California, United States
Los Angeles Biomedical Research Institute
Torrance, California, United States
Empire Clinical Research
Upland, California, United States
University of Colorado
Aurora, Colorado, United States
Centennial - Immunoe International Research
Centennial, Colorado, United States
University of Florida
Gainesville, Florida, United States
Best Quality Research Inc.
Hialeah, Florida, United States
Medical Consulting Center
Miami, Florida, United States
San Marcus Research Clinic, Inc.
Miami, Florida, United States

51 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Amantadine →Oseltamivir →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Sept 2010
Primary completion: 2 May 2016
Completion: 30 Mar 2017
Last update posted: 4 Feb 2019
Registered enrollment: 881
Registry id: NCT01227967

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.