Clinical trialNCT01249625CompletedInterventional

The Respiratory Protection Effectiveness Clinical Trial

SponsorJohns Hopkins UniversityEnrollment2,862CoronavirusInfluenzaParamyxoviridae InfectionsRespiratory Syncytial VirusesRhinovirus

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Despite widespread use of respiratory protective equipment in the U.S. healthcare workplace, there is very little clinical evidence that respirators prevent healthcare personnel (HCP) from airborne infectious diseases. Scientific investigation of this issue has been quite complicated, primarily because the use of respirators has become "the standard of care" for protection against airborne diseases in some instances, even without sufficient evidence to support their use. The key question remains: How well do respirators prevent airborne infectious diseases? The answer to this important question has important medical, public health, political and economic implications.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Charlotte Gaydos, PhD
Johns Hopkins University
Study Director
clinicaltrials.gov ↗
Connie S Price, MD
University of Colorado (Denver Health)
Study Director
clinicaltrials.gov ↗
Derek Cummings, PhD
University of Florida
Study Director
clinicaltrials.gov ↗
Lewis Radonovich, MD
CDC-NIOSH
Principal Investigator
clinicaltrials.gov ↗
Michael Simberkoff, MD
New York Harbor Healthcare System VA
Study Director
clinicaltrials.gov ↗
Nicholas Reich, PhD
University of Massachusetts, Amherst
Study Director
clinicaltrials.gov ↗
Trish M. Perl, MD
UTSouthwestern Medical Center
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

7 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Children'S Hospital Colorado Infectious Disease
Aurora, Colorado, United States
Denver Health Medical Center
Denver, Colorado, United States
Denver Veteran'S Administration Medical Center
Denver, Colorado, United States
Veterans Affairs Medical Center, Washington, Dc
Washington D.C., District of Columbia, United States
Johns Hopkins Health Sytstem
Baltimore, Maryland, United States
Va New York Harbor Healthcare System
New York, New York, United States
Houston Va Medical Center
Houston, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Dec 2010
Primary completion: 31 Mar 2018
Completion: 31 Mar 2018
Last update posted: 25 Apr 2019
Registered enrollment: 2,862
Registry id: NCT01249625

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.