Clinical trialNCT01262560CompletedPhase 2Interventional

Manuka Honey in Preventing Esophagitis-Related Pain in Patients Receiving Chemotherapy and Radiation Therapy For Lung Cancer

SponsorRadiation Therapy Oncology GroupEnrollment163DysphagiaEsophagitisLung CancerPain

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Manuka honey may prevent or reduce esophagitis-related pain caused by chemotherapy and radiation therapy. It is not yet known whether Manuka honey is more effective than standard care in preventing pain. PURPOSE: This randomized phase II clinical trial is studying Manuka honey to see how well it works in preventing esophagitis-related pain in patients receiving chemotherapy and radiation therapy for lung cancer.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Lawrence B. Berk, MD, PhD
Tampa General Hospital, University of South Florida
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

59 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Providence Cancer Center at Providence Hospital
Mobile, Alabama, United States
Ucsf Helen Diller Family Comprehensive Cancer Center
San Francisco, California, United States
Stanford Cancer Center
Stanford, California, United States
Ccop - Christiana Care Health Services
Newark, Delaware, United States
Baptist Cancer Institute - Jacksonville
Jacksonville, Florida, United States
Ccop - Mount Sinai Medical Center
Miami Beach, Florida, United States
Florida Cancer Center - Palatka
Palatka, Florida, United States
Piedmont Fayette Hospital
Fayetteville, Georgia, United States
Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph'S/candler
Savannah, Georgia, United States
Hawaii Medical Center - East
Honolulu, Hawaii, United States
Queen'S Cancer Institute at Queen'S Medical Center
Honolulu, Hawaii, United States
Osf St. Francis Medical Center
Peoria, Illinois, United States
Ccop - Carle Cancer Center
Urbana, Illinois, United States
Parkview Regional Cancer Center at Parkview Health
Fort Wayne, Indiana, United States
Cancer Center at Ball Memorial Hospital
Muncie, Indiana, United States
Lucille P. Markey Cancer Center at University of Kentucky
Lexington, Kentucky, United States
Cape Cod Hospital
Hyannis, Massachusetts, United States
Centracare Clinic - River Campus
Saint Cloud, Minnesota, United States
Regional Cancer Center at Singing River Hospital
Pascagoula, Mississippi, United States
David C. Pratt Cancer Center at St. John'S Mercy
St Louis, Missouri, United States
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
St Louis, Missouri, United States
Payson Center for Cancer Care at Concord Hospital
Concord, New Hampshire, United States
Seacoast Cancer Center at Wentworth - Douglass Hospital
Dover, New Hampshire, United States
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, United States
Elliot Regional Cancer Center at Elliot Hospital
Manchester, New Hampshire, United States
Monmouth Medical Center
Long Branch, New Jersey, United States
Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
Marlton, New Jersey, United States
Ccop - Hematology-Oncology Associates of Central New York
East Syracuse, New York, United States
Highland Hospital of Rochester
Rochester, New York, United States
James P. Wilmot Cancer Center at University of Rochester Medical Center
Rochester, New York, United States
Presbyterian Cancer Center at Presbyterian Hospital
Charlotte, North Carolina, United States
Duke Cancer Institute
Durham, North Carolina, United States
Pardee Memorial Hospital
Hendersonville, North Carolina, United States
Firsthealth Moore Regional Community Hospital Comprehensive Cancer Center
Pinehurst, North Carolina, United States
Rex Cancer Center at Rex Hospital
Raleigh, North Carolina, United States
Wake Forest University Comprehensive Cancer Center
Winston-Salem, North Carolina, United States
Trinity Cancercare Center
Minot, North Dakota, United States
Mercy Cancer Center at Mercy Medical Center
Canton, Ohio, United States
Case Comprehensive Cancer Center
Cleveland, Ohio, United States
Cleveland Clinic Cancer Center at Fairview Hospital
Cleveland, Ohio, United States

19 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Manuka honey in liquid formManuka honey in lozenge formStandard supportive care

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 29 Feb 2012
Primary completion: 28 Feb 2014
Completion: 30 Nov 2014
Last update posted: 31 Aug 2017
Registered enrollment: 163
Registry id: NCT01262560

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.