findmyKOL
Clinical trialNCT01265563CompletedPhase 2Interventional

N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy

SponsorVA Office of Research and DevelopmentEnrollment108Diabetic NephropathyOxidative StressProteinuria
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The study is done to find out whether the combined use of the nutritional supplements N-acetylcysteine and Siliphos (milk thistle extract) corrects the shedding of urine protein and oxidative damage (damage to cells and organs often compared to fast aging) in patients with Type 2 Diabetes Mellitus (T2DM) and diabetic kidney disease.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1 registered facility, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • South Texas Health Care System, San Antonio, Tx

    San Antonio, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

N-acetylcysteine active + high-dose silibin activeN-acetylcysteine active and silibin activeN-acetylcysteine active and silibin placeboN-acetylcysteine placebo and silibin activeN-acetylcysteine placebo and silibin placebo
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Jan 2011
Primary completion
28 Feb 2015
Completion
31 Dec 2016
Last update posted
19 Oct 2018
Registered enrollment
108
Registry id
NCT01265563
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.