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Clinical trialNCT01298401CompletedPhase 1Interventional

Ganitumab and Gemcitabine Hydrochloride Followed by Radiation Therapy, Ganitumab, Capecitabine, and Maintenance Therapy in Treating Patients With Locally Advanced Cancer of the Pancreas

SponsorRadiation Therapy Oncology GroupEnrollment8Pancreatic Cancer
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Monoclonal antibodies, such as ganitumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry cancer-killing substances to them. Drugs used in chemotherapy, such as gemcitabine hydrochloride and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Specialized radiation therapy, such as 3-dimensional conformal radiation therapy, that delivers a high-dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. PURPOSE: This phase I trial is studying the side effects and best dose of ganitumab when given together with gemcitabine hydrochloride followed by radiation therapy, ganitumab, capecitabine, and maintenance therapy in treating patients with locally advanced cancer of the pancreas.

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

10 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • St. Joseph Hospital Regional Cancer Center - Orange

    Orange, California, United States

  • Ccop - Christiana Care Health Services

    Newark, Delaware, United States

  • James Graham Brown Cancer Center at University of Louisville

    Louisville, Kentucky, United States

  • Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

    Baltimore, Maryland, United States

  • James P. Wilmot Cancer Center at University of Rochester Medical Center

    Rochester, New York, United States

  • Summa Center for Cancer Care at Akron City Hospital

    Akron, Ohio, United States

  • Mcglinn Family Regional Cancer Center at Reading Hospital and Medical Center

    Reading, Pennsylvania, United States

  • Northmain Radiation Oncology

    Providence, Rhode Island, United States

  • Rhode Island Hospital Comprehensive Cancer Center

    Providence, Rhode Island, United States

  • M. D. Anderson Cancer Center at University of Texas

    Houston, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
29 Feb 2012
Primary completion
30 Nov 2013
Completion
30 Nov 2013
Last update posted
17 Nov 2015
Registered enrollment
8
Registry id
NCT01298401

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.