Clinical trialNCT01322165CompletedObservational

National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions

SponsorNational Heart, Lung, and Blood Institute (NHLBI)Enrollment3,706Bicuspid Aortic Valve With CoarctationBicuspid Aortic Valve With Family HistoryBicuspid Aortic Valve Without Known Family HistoryEhlers-Danlos SyndromeFBN1, TGFBR1, TGFBR2, ACTA2 or MYH11 Genetic MutationFamilial Thoracic Aortic Aneurysm and Dissections+6 more conditions

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) was initiated in 2006 by the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). GenTAC established a registry of 3706 patients with genetic conditions that may be related to thoracic aortic aneurysms and collected medical data and biologic samples. The study ended in September 2016. Data and samples are available from NHLBI and requests should be made to BioLINCC. See the NHLBI website for more information: https://www.nhlbi.nih.gov/research/resources/gentac/.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Barbara Kroner, PhD, MPH
RTI International
Study Director
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Cheryl L. Maslen, Ph.D.
Oregon Health and Science University
Principal Investigator
clinicaltrials.gov ↗
Dianna M. Milewicz, M.D. Ph.D.
University of Texas Medical School at Houston
Principal Investigator
clinicaltrials.gov ↗
Federico M. Asch, MD,FACC,FASE
MedStar Health
Principal Investigator
clinicaltrials.gov ↗
Jennifer Habashi, MD
Johns Hopkins University
Principal Investigator
clinicaltrials.gov ↗
Kim Eagle, M.D.
University of Michigan
Study Chair
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Ralph Shohet, MD
University of Hawaii
Principal Investigator
clinicaltrials.gov ↗
Reed E. Pyeritz, M.D., Ph.D.
University of Pennsylvania
Principal Investigator
clinicaltrials.gov ↗
Richard Devereux, MD
The New York Presbyterian Hospital-Weill Cornell Medical Center
Principal Investigator
clinicaltrials.gov ↗
Scott A. LeMaire, M.D.
Baylor College of Medicine
Principal Investigator
clinicaltrials.gov ↗
William Ravekes, M.D.
Johns Hopkins University
Principal Investigator
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

7 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Queens Medical Center
Honolulu, Hawaii, United States
Johns Hopkins University
Baltimore, Maryland, United States
the New York Presbyterian Hospital-Weill Cornell Medical Center
New York, New York, United States
Oregon Health & Science University
Portland, Oregon, United States
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania, United States
Baylor College of Medicine
Houston, Texas, United States
University of Texas Medical School at Houston
Houston, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Nov 2007
Primary completion: 30 Sept 2015
Completion: 30 Sept 2016
Last update posted: 20 Dec 2016
Registered enrollment: 3,706
Registry id: NCT01322165

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.