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Clinical trialNCT01349322Active, not recruitingPhase 3Interventional

Higher Per Daily Treatment-Dose Radiation Therapy or Standard Per Daily Treatment Radiation Therapy in Treating Patients With Early-Stage Breast Cancer That Was Removed by Surgery

SponsorRadiation Therapy Oncology GroupEnrollment2,354Breast Cancer
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: It is not yet know whether higher per daily radiation therapy is equally as effective as standard per daily radiation therapy in treating breast cancer. PURPOSE: This randomized phase III trial studies how well an accelerated course of higher per daily radiation therapy with concomitant boost works compared to standard per daily radiation therapy with a sequential boost in treating patients with early-stage breast cancer that was removed by surgery.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

415 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada
  • Cross Cancer Institute

    Edmonton, Alberta, Canada

  • Bcca-Vancouver Cancer Centre

    Vancouver, British Columbia, Canada

  • Cancercare Manitoba

    Winnipeg, Manitoba, Canada

  • Atlantic Health Sciences Corporation-Saint John Regional Hospital

    Saint John, New Brunswick, Canada

  • Grand River Regional Cancer Centre at Grand River Hospital

    Kitchener, Ontario, Canada

  • London Regional Cancer Program

    London, Ontario, Canada

  • Stronach Regional Health Centre at Southlake

    Newmarket, Ontario, Canada

  • Irving Greenberg Family Cancer Centre

    Ottawa, Ontario, Canada

  • Ottawa Hospital and Cancer Center-General Campus

    Ottawa, Ontario, Canada

  • Ottawa Hospital-Civic Campus

    Ottawa, Ontario, Canada

  • Windsor Regional Cancer Centre

    Windsor, Ontario, Canada

  • Hopital de la Cite-de-la-Sante

    Laval, Quebec, Canada

  • Chum - Centre Hospitalier de L'Universite de Montreal

    Montreal, Quebec, Canada

  • Chum - Hopital Notre-Dame

    Montreal, Quebec, Canada

  • Ciusssemtl-Hopital Maisonneuve-Rosemont

    Montreal, Quebec, Canada

  • Mcgill University Department of Oncology

    Montreal, Quebec, Canada

  • the Research Institute of the Mcgill University Health Centre (muhc)

    Montreal, Quebec, Canada

  • Chu de Quebec-L'Hotel-Dieu de Quebec (hdq)

    Québec, Quebec, Canada

  • Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

    Sherbrooke, Quebec, Canada

  • Allan Blair Cancer Centre

    Regina, Saskatchewan, Canada

Hong Kong
  • Pamela Youde Nethersole Eastern Hospital

    Chai Wan, Hong Kong

Israel
  • Rabin Medical Center

    Petah Tikva, Israel

  • Chaim Sheba Medical Center

    Tel Litwinsky, Israel

Japan
  • Shizuoka Cancer Center

    Shizuoka, Suntou, Japan

Singapore
  • National Cancer Centre Singapore

    Singapore, Singapore

  • National University Hospital Singapore

    Singapore, Singapore

South Korea
  • National Cancer Center-Korea

    Goyang-si, Gyeonggi-do, South Korea

  • Yonsei University Health System-Severance Hospital

    Seoul, South Korea

Switzerland
  • Kantonsspital Aarau

    Aarau, Switzerland

United States
  • the Kirklin Clinic at Acton Road

    Birmingham, Alabama, United States

  • University of Alabama at Birmingham Cancer Center

    Birmingham, Alabama, United States

  • 21st Century Oncology-Scottsdale

    Scottsdale, Arizona, United States

  • Mayo Clinic in Arizona

    Scottsdale, Arizona, United States

  • Arizona Oncology Associates-West Orange Grove

    Tucson, Arizona, United States

  • Banner University Medical Center - Tucson

    Tucson, Arizona, United States

  • Chi Saint Vincent Cancer Center Hot Springs

    Hot Springs, Arkansas, United States

  • University of Arkansas for Medical Sciences

    Little Rock, Arkansas, United States

  • Sutter Cancer Centers Radiation Oncology Services-Auburn

    Auburn, California, United States

  • Sutter Cancer Centers Radiation Oncology Services-Cameron Park

    Cameron Park, California, United States

  • Mercy San Juan Medical Center

    Carmichael, California, United States

375 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study — it may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
24 May 2011
Primary completion
25 Jan 2022
Completion
Last update posted
5 Mar 2026
Registered enrollment
2,354
Registry id
NCT01349322

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.