Clinical trialNCT01369069CompletedPhase 3Interventional

Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial

SponsorUniversity of VirginiaEnrollment1,151Acute Ischemic StrokeDiabetesHyperglycemia

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial is a multicenter, randomized, controlled clinical trial of 1400 patients that will include approximately 60 enrolling sites. The study hypotheses are that treatment of hyperglycemic acute ischemic stroke patients with targeted glucose concentration (80mg/dL - 130 mg/dL) will be safe and result in improved 3 month outcome after stroke.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Askiel Bruno, MD, MS
Augusta University
Principal Investigator
clinicaltrials.gov ↗
Christiana Hall, MD, MS
UT Southwestern
Principal Investigator
clinicaltrials.gov ↗
Karen C Johnston, MD, MSc
University of Virginia
Study Chair
clinicaltrials.gov ↗
Kevin Barrett, MD
Mayo Clinic
Principal Investigator
clinicaltrials.gov ↗
Valerie Durkalski, PhD
Medical University of South Carolina
Principal Investigator
clinicaltrials.gov ↗
William Barsan, MD
University of Michigan
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

70 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Arizona
Tucson, Arizona, United States
University of Arizona Medical Center - South Campus
Tucson, Arizona, United States
Long Beach Memorial Medical Center
Long Beach, California, United States
Ronald Regan Medical Center
Los Angeles, California, United States
California Pacific Medical Center - Davies Campus
San Francisco, California, United States
California Pacific Medical Center-Pacific Campus
San Francisco, California, United States
San Francisco General Hospital
San Francisco, California, United States
Ucsf Medical Center
San Francisco, California, United States
Stanford University Medical Center
Stanford, California, United States
Medstar Washington Hospital Center
Washington D.C., District of Columbia, United States
Mayo Clinic Jacksonville
Jacksonville, Florida, United States
Jackson Memorial Hospital
Miami, Florida, United States
Emory University Hospital
Atlanta, Georgia, United States
Emory University Hospital - Midtown
Atlanta, Georgia, United States
Grady Memorial Hospital
Atlanta, Georgia, United States
Augusta University Medical Center
Augusta, Georgia, United States
Northwestern Memorial Hospital
Chicago, Illinois, United States
Osf Saint Francis Medical Center
Peoria, Illinois, United States
University of Iowa Hospitals & Clinics
Iowa City, Iowa, United States
University of Kansas Medical Center
Kansas City, Kansas, United States
University of Kentucky
Lexington, Kentucky, United States
University of Maryland Medical Center
Baltimore, Maryland, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Tufts Medical Center
Boston, Massachusetts, United States
University of Michigan
Ann Arbor, Michigan, United States
Detroit Receiving Hospital
Detroit, Michigan, United States
Henry Ford Health System
Detroit, Michigan, United States
Sinai-Grace Hospital
Detroit, Michigan, United States
William Beaumont Hospital-Royal Oak
Royal Oak, Michigan, United States
William Beaumont Hospital-Troy
Troy, Michigan, United States
Hennepin County Medical Center
Minneapolis, Minnesota, United States
University of Minnesota Medical Center, Fairview
Minneapolis, Minnesota, United States
Jfk Medical Center
Edison, New Jersey, United States
Hackensack University Medical Center
Hackensack, New Jersey, United States
Kings County Hospital
Brooklyn, New York, United States
Suny Downstate University Hospital of Brooklyn
Brooklyn, New York, United States
Buffalo General Medical Center
Buffalo, New York, United States
Columbia University Medical Center
New York, New York, United States
Maimonides Medical Center
New York, New York, United States
the Mount Sinai Medical Center
New York, New York, United States

30 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

IV insulin to maintain target glucose concentration of 80-130 mg/dLStandard Care control - sliding scale insulin to keep glucose less than 180 mg/dL

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Apr 2012
Primary completion: 19 Nov 2018
Completion: 19 Nov 2018
Last update posted: 23 Dec 2019
Registered enrollment: 1,151
Registry id: NCT01369069

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.