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Clinical trialNCT01369849CompletedPhase 1/PHASE2Interventional

Akt Inhibitor MK2206, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

SponsorNational Cancer Institute (NCI)Enrollment15Chronic Lymphocytic LeukemiaRecurrent Small Lymphocytic LymphomaRefractory Chronic Lymphocytic Leukemia
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase I/II trial studies the side effects and best dose of v-akt murine thymoma viral oncogene homolog 1 (Akt) inhibitor MK2206 when given together with bendamustine hydrochloride and rituximab and to see how well they work in treating patients with refractory chronic lymphocytic leukemia or small lymphocytic lymphoma. Akt inhibitor MK2206 may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as bendamustine hydrochloride, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Giving Akt inhibitor MK2206 with bendamustine hydrochloride and rituximab may be an effective treatment for relapsed chronic lymphocytic leukemia or small lymphocytic lymphoma.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

44 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Mayo Clinic in Arizona

    Scottsdale, Arizona, United States

  • Mercy Medical Center-Sioux City

    Sioux City, Iowa, United States

  • Saint Luke'S Regional Medical Center

    Sioux City, Iowa, United States

  • Siouxland Regional Cancer Center

    Sioux City, Iowa, United States

  • Essentia Health Saint Joseph'S Medical Center

    Brainerd, Minnesota, United States

  • Fairview Ridges Hospital

    Burnsville, Minnesota, United States

  • Mercy Hospital

    Coon Rapids, Minnesota, United States

  • Essentia Health Cancer Center

    Duluth, Minnesota, United States

  • Essentia Health Saint Mary'S Medical Center

    Duluth, Minnesota, United States

  • Miller-Dwan Hospital

    Duluth, Minnesota, United States

  • Fairview-Southdale Hospital

    Edina, Minnesota, United States

  • Unity Hospital

    Fridley, Minnesota, United States

  • Hutchinson Area Health Care

    Hutchinson, Minnesota, United States

  • Minnesota Oncology Hematology Pa-Maplewood

    Maplewood, Minnesota, United States

  • Saint John'S Hospital - Healtheast

    Maplewood, Minnesota, United States

  • Abbott-Northwestern Hospital

    Minneapolis, Minnesota, United States

  • Hennepin County Medical Center

    Minneapolis, Minnesota, United States

  • North Memorial Medical Health Center

    Robbinsdale, Minnesota, United States

  • Mayo Clinic

    Rochester, Minnesota, United States

  • Metro-Minnesota Nci Community Oncology Research Program

    Saint Louis Park, Minnesota, United States

  • Park Nicollet Clinic - Saint Louis Park

    Saint Louis Park, Minnesota, United States

  • Regions Hospital

    Saint Paul, Minnesota, United States

  • United Hospital

    Saint Paul, Minnesota, United States

  • Saint Francis Regional Medical Center

    Shakopee, Minnesota, United States

  • Lakeview Hospital

    Stillwater, Minnesota, United States

  • Ridgeview Medical Center

    Waconia, Minnesota, United States

  • Rice Memorial Hospital

    Willmar, Minnesota, United States

  • Minnesota Oncology and Hematology Pa-Woodbury

    Woodbury, Minnesota, United States

  • Adena Regional Medical Center

    Chillicothe, Ohio, United States

  • Columbus Ccop

    Columbus, Ohio, United States

  • Doctors Hospital

    Columbus, Ohio, United States

  • Grant Medical Center

    Columbus, Ohio, United States

  • Mount Carmel Health Center West

    Columbus, Ohio, United States

  • Riverside Methodist Hospital

    Columbus, Ohio, United States

  • Grady Memorial Hospital

    Delaware, Ohio, United States

  • Fairfield Medical Center

    Lancaster, Ohio, United States

  • Marietta Memorial Hospital

    Marietta, Ohio, United States

  • Knox Community Hospital

    Mount Vernon, Ohio, United States

  • Licking Memorial Hospital

    Newark, Ohio, United States

  • Southern Ohio Medical Center

    Portsmouth, Ohio, United States

4 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Akt Inhibitor MK2206 →Bendamustine →Rituximab →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
30 Sept 2011
Primary completion
28 Feb 2014
Completion
28 Feb 2014
Last update posted
15 Sept 2017
Registered enrollment
15
Registry id
NCT01369849
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.