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Clinical trialNCT01411852CompletedPhase 2Interventional

Field Trial of Hypotensive Versus Standard Resuscitation for Hemorrhagic Shock After Trauma

SponsorUniversity of WashingtonEnrollment192Blunt TraumaHemorrhagic ShockPenetrating Wound
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Primary Aim: To determine the feasibility and safety of hypotensive resuscitation for the early treatment of patients with traumatic shock compared to standard fluid resuscitation. Primary Hypotheses: The null hypothesis regarding feasibility is that hypotensive resuscitation will result in the same volume of early crystalloid (normal saline) fluid administration compared to standard crystalloid resuscitation. The null hypothesis regarding safety is that hypotensive resuscitation will result in the same percent of patients surviving to 24 hours after 911 call received at dispatch compared to standard fluid resuscitation. Early resuscitation is defined as all fluid given until 2 hours after arrival in the Emergency Department or until hemorrhage control is achieved in the hospital, whichever occurs earlier.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

6 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada
  • Resuscitation Outcomes Consortium Regional Coordinating Center,university of British Columbia

    Vancouver, British Columbia, Canada

United States
  • Alabama Resuscitation Center, University of Alabama

    Birmingham, Alabama, United States

  • Portland Resuscitation Outcomes Consortium, Oregon Health & Sciences University

    Portland, Oregon, United States

  • the Pittsburgh Resuscitation Network, University of Pittsburgh

    Pittsburgh, Pennsylvania, United States

  • Dallas Center for Resuscitation Research, University of Texas Southwestern Medical Center

    Dallas, Texas, United States

  • Milwaukee Resuscitation Network, Medical College of Wisconsin

    Milwaukee, Wisconsin, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Mar 2012
Primary completion
30 Apr 2013
Completion
30 Apr 2013
Last update posted
13 Jan 2015
Registered enrollment
192
Registry id
NCT01411852

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.