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Clinical trialNCT01435018CompletedPhase 3Interventional

Three Chemo Regimens as an Adjunct to ART for Treatment of Advanced AIDS-KS

SponsorAdvancing Clinical Therapeutics Globally for HIV/AIDS and Other InfectionsEnrollment334HIV-1 Infection
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This study was done to compare the safety and efficacy of three combination treatments for Kaposi's Sarcoma (KS) and AIDS: 1. Etoposide (ET) plus co-formulated Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate (EFV/FTC/TDF) (ET+ART), 2. Bleomycin and Vincristine (BV) plus co-formulated EFV/FTC/TDF (BV+ART), 3. Paclitaxel (PTX) plus co-formulated EFV/FTC/TDF (PTX+ART).
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

11 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Brazil
  • Instituto de Pesquisa Clinica Evandro Chagas (12101)

    Rio de Janeiro, Brazil

Kenya
  • Moi University International Clnical Trials Unit

    Eldoret, Kenya

  • Kmri / Walter Reed Project Clinical Research Center

    Kericho, Kenya

  • Kenya Medical Research Institute/center for Disease Control (kemri/cdc) Crs (31460)

    Kisumu, Kenya

Malawi
  • Univ. of Malawi, John Hopkins Project

    Blantyre, Malawi

  • Malawi Crs (12001)

    Lilongwe, Malawi

South Africa
  • Family Clinical Research Unit (fam-Cur) Crs (8950)

    Cape Town, West Cape, South Africa

  • Durban Adult Hiv Crs (11201)

    Durban, South Africa

  • University of Witwatersrand

    Johannesburg, South Africa

Uganda
  • Uganda Cancer Institute Actg Crs

    Kampala, Uganda

Zimbabwe
  • Uz-Parirenyatwa Crs (30313)

    Harare, Zimbabwe

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Bleomycin and VincristineCo-formulated Efavirenz/Emtricitabine/Tenofovir Disoproxil FumarateEtoposide →Paclitaxel →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
1 Oct 2013
Primary completion
13 Mar 2018
Completion
29 Aug 2019
Last update posted
20 Oct 2021
Registered enrollment
334
Registry id
NCT01435018
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.