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Clinical trialNCT01533207TerminatedPhase 3Interventional

Gemcitabine Hydrochloride and Docetaxel Followed by Doxorubicin Hydrochloride or Observation in Treating Patients With High-Risk Uterine Leiomyosarcoma Previously Removed by Surgery

SponsorGynecologic Oncology GroupEnrollment38Stage I Uterine Sarcoma AJCC v7Uterine Corpus Leiomyosarcoma
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This randomized phase III trial studies how well gemcitabine hydrochloride and docetaxel followed by doxorubicin hydrochloride work compared to observation in treating patients with high-risk uterine leiomyosarcoma previously removed by surgery. Drugs used in chemotherapy, such as gemcitabine hydrochloride, docetaxel, and doxorubicin hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether combination therapy after surgery is an effective treatment for uterine leiomyosarcoma.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

623 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Belgium
  • Universitair Ziekenhuis Antwerpen

    Edegem, Belgium

France
  • Institut Bergonie Cancer Center

    Bordeaux, France

  • Centre Georges-Francois Leclerc

    Dijon, France

  • Centre Leon Berard

    Lyon, France

  • Centre Catherine de Sienne

    Nantes, France

Netherlands
  • University Medical Center Groningen

    Groningen, Netherlands

Norway
  • University of Oslo

    Oslo, Norway

Spain
  • Hospital Clinico San Carlos

    Madrid, Spain

United Kingdom
  • Addenbrookes Hospital-Medical School

    Cambridge, England, United Kingdom

  • University College London Hospital

    London, England, United Kingdom

  • Christie Hospital

    Manchester, England, United Kingdom

  • Weston Park Hospital

    Sheffield, England, United Kingdom

  • Beatson Oncology Center

    Glasgow, Scotland, United Kingdom

  • Institute of Cancer Research - Chelsea

    London, United Kingdom

United States
  • Tennessee Valley Gynecologic Oncology

    Huntsville, Alabama, United States

  • Alaska Breast Care and Surgery Llc

    Anchorage, Alaska, United States

  • Alaska Oncology and Hematology Llc

    Anchorage, Alaska, United States

  • Alaska Regional Hospital

    Anchorage, Alaska, United States

  • Alaska Women'S Cancer Care

    Anchorage, Alaska, United States

  • Anchorage Associates in Radiation Medicine

    Anchorage, Alaska, United States

  • Anchorage Oncology Centre

    Anchorage, Alaska, United States

  • Anchorage Radiation Therapy Center

    Anchorage, Alaska, United States

  • Katmai Oncology Group

    Anchorage, Alaska, United States

  • Providence Alaska Medical Center

    Anchorage, Alaska, United States

  • Fairbanks Memorial Hospital

    Fairbanks, Alaska, United States

  • Chi Saint Vincent Cancer Center Hot Springs

    Hot Springs, Arkansas, United States

  • Kaiser Permanente-Deer Valley Medical Center

    Antioch, California, United States

  • Sutter Auburn Faith Hospital

    Auburn, California, United States

  • Sutter Cancer Centers Radiation Oncology Services-Auburn

    Auburn, California, United States

  • Alta Bates Summit Medical Center-Herrick Campus

    Berkeley, California, United States

  • Providence Saint Joseph Medical Center/disney Family Cancer Center

    Burbank, California, United States

  • Mills-Peninsula Medical Center

    Burlingame, California, United States

  • Sutter Cancer Centers Radiation Oncology Services-Cameron Park

    Cameron Park, California, United States

  • Sutter Davis Hospital

    Davis, California, United States

  • Kaiser Permanente-Fremont

    Fremont, California, United States

  • Kaiser Permanente-Fresno

    Fresno, California, United States

  • Uc San Diego Moores Cancer Center

    La Jolla, California, United States

  • Loma Linda University Medical Center

    Loma Linda, California, United States

  • Kaiser Permanente Los Angeles Medical Center

    Los Angeles, California, United States

  • Kaiser Permanente-Modesto

    Modesto, California, United States

583 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
4 Jun 2012
Primary completion
30 Jun 2018
Completion
9 Feb 2019
Last update posted
28 Apr 2020
Registered enrollment
38
Registry id
NCT01533207

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.