Clinical trialNCT01594333CompletedPhase 3Interventional

Cardiovascular Inflammation Reduction Trial

SponsorBrigham and Women's HospitalEnrollment4,786Cardiovascular Disease

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The Cardiovascular Inflammation Reduction Trial (CIRT) is a randomized clinical trial investigating whether taking low-dose methotrexate reduces heart attacks, strokes, or death in people with type 2 diabetes or metabolic syndrome that have had a heart attack or multiple coronary blockages. This trial is funded by the National Heart, Lung, and Blood Institute (NHLBI)/National Institutes of Health (NIH).

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Paul Ridker, MD, MPH
Brigham and Women's Hospital
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

470 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

the Medical Arts Health Research Group
North Vancouver, British Columbia, Canada
the Medical Arts Health Research Group
Penticton, British Columbia, Canada
Winnipeg Clinic
Winnipeg, Manitoba, Canada
Bramalea Medical Centre
Brampton, Ontario, Canada
Brampton Research Associates
Brampton, Ontario, Canada
Philippe R Beaudry Medicine Professional Corporation
Burlington, Ontario, Canada
Vizel Cardiac Research
Cambridge, Ontario, Canada
Dr. Linda Sinnaeve'S Office
Chatham, Ontario, Canada
Scisco Clinical Research
Cornwall, Ontario, Canada
Dr. G. Garrioch, Independent Practice
Greater Sudbury, Ontario, Canada
Dr. R. Labonte Professional Med Corp
Greater Sudbury, Ontario, Canada
G.S. Cardiac Lab Medicine Professional Corp
Greater Sudbury, Ontario, Canada
Dr. Peter Spadafora Health Center
Guelph, Ontario, Canada
Dr. William Liang
Hamilton, Ontario, Canada
John Stimac, Md
Hamilton, Ontario, Canada
Kmh Cardiology & Diagnostics: Hamilton
Hamilton, Ontario, Canada
Source Unique Clinic
Hawkesbury, Ontario, Canada
Dr. Ronald Fowlis
Kitchener, Ontario, Canada
University Hospital
London, Ontario, Canada
Kmh Cardiology & Diagnostics: Mississauga
Mississauga, Ontario, Canada
Malton Medical Research
Mississauga, Ontario, Canada
Sewa Ram Singal Medicine Professional Corporation
Mississauga, Ontario, Canada
Newmarket Cardiology Research Group
Newmarket, Ontario, Canada
Newmarket Cardiology Research Group
Newmarket, Ontario, Canada
Portage Medical Centre
Niagara Falls, Ontario, Canada
Humber River Regional Hospital
North York, Ontario, Canada
Bakbak Medicine Professional Corporation
Oshawa, Ontario, Canada
Dr. James Y. Cha
Oshawa, Ontario, Canada
University of Ottawa Heart Institute
Ottawa, Ontario, Canada
Kawartha Cardiology Clinical Trials
Peterborough, Ontario, Canada
Steeple Hill Medical Centre
Pickering, Ontario, Canada
Sarnia Institute of Clinical Research
Sarnia, Ontario, Canada
Milliken Medical Centre
Scarborough Village, Ontario, Canada
Scarborough Cardiology Research
Scarborough Village, Ontario, Canada
Scarborough General Hospital Cardiology Research Associates
Scarborough Village, Ontario, Canada
Canadian Centre for Research on Diabetes
Smith Falls, Ontario, Canada
Lake Shore Cardiology
St. Catharines, Ontario, Canada
Sardar Medical Clinic
St. Thomas, Ontario, Canada
Dr. Laurence Gibbs Medicine Professional Corp.
Thedford, Ontario, Canada
Tillsonburg Medical Centre
Tillsonburg, Ontario, Canada

430 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Methotrexate →Placebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Apr 2013
Primary completion: 15 Apr 2019
Completion: 30 Oct 2019
Last update posted: 24 Jul 2020
Registered enrollment: 4,786
Registry id: NCT01594333

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.