Clinical trialNCT01730950CompletedPhase 2Interventional

Bevacizumab With or Without Radiation Therapy in Treating Patients With Recurrent Glioblastoma

SponsorRadiation Therapy Oncology GroupEnrollment182Adult Giant Cell GlioblastomaAdult GlioblastomaAdult GliosarcomaRecurrent Adult Brain Tumor

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This randomized phase II trial studies how well bevacizumab with or without radiation therapy works in treating patients with recurrent glioblastoma. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry cancer-killing substances to them. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. It is not yet know whether bevacizumab is more effective with or without radiation therapy in treating patients with recurrent glioblastoma

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Adam P. Dicker, MD, PhD
Jefferson Medical College of Thomas Jefferson University
Study Chair
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Christina Tsien
Washington University School of Medicine
Principal Investigator
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Jeffrey Raizer, MD
Northwestern University
Study Chair
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Martha M. Matuszak, PhD
University of Michigan
Study Chair
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

31 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Alabama at Birmingham
Birmingham, Alabama, United States
Arizona Oncology Services Foundation
Phoenix, Arizona, United States
Arizona Oncology-Deer Valley Center
Phoenix, Arizona, United States
John Muir Medical Center
Walnut Creek, California, United States
Yale University
New Haven, Connecticut, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, United States
Queen'S Medical Center
Honolulu, Hawaii, United States
Radiation Oncology Associates Pc
Fort Wayne, Indiana, United States
Iu Health Methodist Hospital
Indianapolis, Indiana, United States
Memorial Hospital of South Bend
South Bend, Indiana, United States
Norton Health Care Pavilion - Downtown
Louisville, Kentucky, United States
Maine Medical Center- Scarborough Campus
Scarborough, Maine, United States
Lowell General Hospital
Lowell, Massachusetts, United States
University of Michigan University Hospital
Ann Arbor, Michigan, United States
West Michigan Cancer Center
Kalamazoo, Michigan, United States
Washington University School of Medicine
St Louis, Missouri, United States
Nebraska Methodist Hospital
Omaha, Nebraska, United States
University of Rochester
Rochester, New York, United States
Cone Health Cancer Center
Greensboro, North Carolina, United States
Summa Akron City Hospital
Akron, Ohio, United States
Summa Barberton Hospital
Barberton, Ohio, United States
Lancaster General Hospital
Lancaster, Pennsylvania, United States
Radiation Therapy Oncology Group
Philadelphia, Pennsylvania, United States
Allegheny Cancer Center at Allegheny General Hospital
Pittsburgh, Pennsylvania, United States
Medical University of South Carolina
Charleston, South Carolina, United States
University of Texas Medical Branch
Galveston, Texas, United States
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima, Washington, United States
Saint Mary'S Hospital
Green Bay, Wisconsin, United States
Saint Vincent Hospital
Green Bay, Wisconsin, United States
Bay Area Medical Center
Marinette, Wisconsin, United States
Door County Cancer Center
Sturgeon Bay, Wisconsin, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Bevacizumab →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 20 Dec 2012
Primary completion: 3 Sept 2018
Completion: 22 Dec 2022
Last update posted: 29 Dec 2022
Registered enrollment: 182
Registry id: NCT01730950

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.